MORPHOLOGISCHE PROGNOSEKRITERIEN UND KLINISCHER VERLAUF BEI OVARIALTUMOREN VOM 'BORDERLINE-TYP'

Translated title of the contribution: Morphologic prognosis criteria and clinical course in 'borderline-type' ovarian tumors

W. Kühn, J. Hanke, G. E. Feichter, H. H. Rummel, H. Schmid, W. Schmidt, M. Kaufmann

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Borderline tumors of the ovary are morphologically characterized by histologic and cellular criteria and by lack of evidence of invasion. During an observation period of 12 years at Heidelberg University Gynecological Clinic, 49 patients with borderline tumors underwent surgery and the clinical course was followed up. In 15 cases the tumor was at an advanced stage (FIGO III/IV); chemotherapy was instituted after surgery in 12 of these women. None of the patients with early-stage tumors (FIGO I/II) were lost due to the tumor during the period of observation; the death rate among patients with stage III/IV tumors (FIGO) was 40%. However, the death of three of these women was also due to their advanced age and high internal risks. As in the case of ovarian carcinomas, the survival rates improve if the postoperative residual tumor mass is smaller than 2 cm. Subsequent histologic work-up of archived, formalin-fixed tumor tissue and metastases thereof showed that two forms of the metastasizing borderling tumor exist: one with a favorable prognosis, a 'pure' form with borderline changes in the ovary and metastases, and one with a less favorable prognosis, with borderline changes in the ovary and destructive-invasive portions of tumor in the metastazation areas. Impulse cytophotometric studies (ICP) showed that all primary tumors had the same degree of ploidy i.e., diploid. However, detection of an aneuploid distribution pattern in a metastasis correlated with subsequent histological confirmation of tumor invasion and rapid tumor death. The S-phase fraction was low, at 2.02% ± 1.3. These investigations emphasize the need for schematic work-up not only of primary tumors, but also of intra-abdominal metastases. ICP is a useful diagnostic method which can be used routinely as an aid in the difficult differential diagnosis between the borderline tumors and invasive carcinomas. When cytokinetic measurements are atypical, subsequent histological work-up and appraisal are advisable in order to rule out the possibility of invasive tumor portions.

Translated title of the contributionMorphologic prognosis criteria and clinical course in 'borderline-type' ovarian tumors
Original languageGerman
Pages (from-to)173-178
Number of pages6
JournalGeburtshilfe und Frauenheilkunde
Volume47
Issue number3
DOIs
StatePublished - 1987
Externally publishedYes

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