Monozyten und Makrophagen im direkten Kontakt mit TiAl6V4-Implantaten Eine In-vitro-Zytokinexpressionsstudie

Sybille Warmuth; Michaela Kosmann; Joachim Aigner; Erich Wintermantel; Dieter Scharnweber; Hartmut Worch

doi:10.3139/120.100640

Monozyten und Makrophagen im direkten Kontakt mit TiAl6V4-Implantaten Eine In-vitro-Zytokinexpressionsstudie

Translated title of the contribution: Monocytes and makronhages in contact with various coated Ti6Al4V implants - In vitro expression of cytokines

Sybille Warmuth, Michaela Kosmann, Joachim Aigner, Erich Wintermantel, Dieter Scharnweber, Hartmut Worch

Chair of Ergonomics

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Mono cytes/Macrophages play a crucial role regarding the tissue interaction of biomaterials by producing proinflammatory mediators. In the present study, we investigate the phagocytic inflammation of several surface precoated Ti6Al4V implants. The various surfaces trigger different cytokine expression by primary blood monocytes. The in vitro cell culture model mimics cell-biomaterials interactions and identifies materials with the highest inflammatory power. However the relevance of these results concerning the in vivo behaviour of implant surface needs further validation.

Translated title of the contribution	Monocytes and makronhages in contact with various coated Ti6Al4V implants - In vitro expression of cytokines
Original language	German
Pages (from-to)	107-111
Number of pages	5
Journal	Materialpruefung/Materials Testing
Volume	47
Issue number	3
DOIs	https://doi.org/10.3139/120.100640
State	Published - 2005

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abstract = "Mono cytes/Macrophages play a crucial role regarding the tissue interaction of biomaterials by producing proinflammatory mediators. In the present study, we investigate the phagocytic inflammation of several surface precoated Ti6Al4V implants. The various surfaces trigger different cytokine expression by primary blood monocytes. The in vitro cell culture model mimics cell-biomaterials interactions and identifies materials with the highest inflammatory power. However the relevance of these results concerning the in vivo behaviour of implant surface needs further validation.",

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AU - Kosmann, Michaela

AU - Aigner, Joachim

AU - Wintermantel, Erich

AU - Scharnweber, Dieter

AU - Worch, Hartmut

PY - 2005

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N2 - Mono cytes/Macrophages play a crucial role regarding the tissue interaction of biomaterials by producing proinflammatory mediators. In the present study, we investigate the phagocytic inflammation of several surface precoated Ti6Al4V implants. The various surfaces trigger different cytokine expression by primary blood monocytes. The in vitro cell culture model mimics cell-biomaterials interactions and identifies materials with the highest inflammatory power. However the relevance of these results concerning the in vivo behaviour of implant surface needs further validation.

AB - Mono cytes/Macrophages play a crucial role regarding the tissue interaction of biomaterials by producing proinflammatory mediators. In the present study, we investigate the phagocytic inflammation of several surface precoated Ti6Al4V implants. The various surfaces trigger different cytokine expression by primary blood monocytes. The in vitro cell culture model mimics cell-biomaterials interactions and identifies materials with the highest inflammatory power. However the relevance of these results concerning the in vivo behaviour of implant surface needs further validation.

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Monozyten und Makrophagen im direkten Kontakt mit TiAl6V4-Implantaten Eine In-vitro-Zytokinexpressionsstudie

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