Monoclonal antibodies to human myelomonocyte differentiation antigens in the diagnosis of acute myeloid leukemia

Walter Knapp, Otto Majdic, Hannes Stockinger, Peter Bettelheim, Kristof Liszka, Ursula Köller, Christian Peschel

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

The immunological definition of malignant lymphatic cells has already been routinely applied by many laboratories over a number of years. Today it is clear and undisputed that the phenotypic data obtained in that way are often very useful and supporting. The immunological definition of non-lymphoid leukemias is not yet as far advanced. Additional surface markers for the recognition of poorly differentiated non-lymphoid cells are clearly needed. In this paper ten monoclonal antibodies to myeloid surface antigens are described. It is hoped that they are a useful addition to the presently available relatively small panel of well studied myeloid surface markers which are displayed by immature malignant blast cells.

Original languageEnglish
Pages (from-to)257-262
Number of pages6
JournalMedical Oncology and Tumor Pharmacotherapy
Volume1
Issue number4
DOIs
StatePublished - Dec 1984
Externally publishedYes

Keywords

  • Differentiation antigens
  • Leukemia
  • Monoclonal antibodies
  • Myeloid

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