Molekularpathologische diagnostik solider tumoren. Was ist klinisch relevant?

Translated title of the contribution: Molecular pathology diagnostics in solid tumors. What is clinically relevant?

M. Werner, A. D. Cabras, H. Höfler

Research output: Contribution to journalArticlepeer-review

Abstract

There are only a few clinically relevant applications of molecular pathology assays in solid tumors. Among the findings which may influence therapy decisions are the amplification of Her-2/new in breast cancer and specific translocations in sarcomas. Mutation analyses of p53 may be helpful for only a very few cases, e.g. for confirming high grade dysplasia in the upper gastrointestinal tract or for diagnosing malignant soft tissue tumors in isolated cases. Microsatellite analyses are important for HNPCC screening or distinguishing tissue specimens of questionable identity. Other applications of molecular pathology assays such as detection of minimal residual disease or tumor cell dissemination and FISH analysis of urine and effusion specimens, may be increasingly applied in the future.

Translated title of the contributionMolecular pathology diagnostics in solid tumors. What is clinically relevant?
Original languageGerman
Pages (from-to)170-173
Number of pages4
JournalPathologe
Volume23
Issue number3
DOIs
StatePublished - 2002

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