Abstract
Hyperthermia treatment in the temperature range 39-43°C can influence the adaptive and natural immune system in addition to the direct toxic effect of temperatures above 41°C on cells. The type of cell destruction (necrosis or apoptosis) plays an important role in whether a pro-inflammatory or anti-inflammatory immune response is triggered by hyperthermia. In addition danger signals, such as high mobility group B1 protein, adenosine-5-triphosphate (ATP) and heat-shock protein, which are released from necrotic tumor cells, can stimulate cells of the natural immune system and therefore assist the anti-tumor response. In this review article the various molecular and immunological mechanisms which are regulated by hyperthermia treatment will be described in detail.
Translated title of the contribution | Molecular and immunological effects of hyperthermia on tumor progression and metastasis |
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Original language | German |
Pages (from-to) | 1043-1051 |
Number of pages | 9 |
Journal | Onkologe |
Volume | 16 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2010 |