Molekulare und immunologische effekte der hyperthermie auf tumorprogression und metastasierung

Translated title of the contribution: Molecular and immunological effects of hyperthermia on tumor progression and metastasis

G. Multhoff, U. Gaipl

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Hyperthermia treatment in the temperature range 39-43°C can influence the adaptive and natural immune system in addition to the direct toxic effect of temperatures above 41°C on cells. The type of cell destruction (necrosis or apoptosis) plays an important role in whether a pro-inflammatory or anti-inflammatory immune response is triggered by hyperthermia. In addition danger signals, such as high mobility group B1 protein, adenosine-5-triphosphate (ATP) and heat-shock protein, which are released from necrotic tumor cells, can stimulate cells of the natural immune system and therefore assist the anti-tumor response. In this review article the various molecular and immunological mechanisms which are regulated by hyperthermia treatment will be described in detail.

Translated title of the contributionMolecular and immunological effects of hyperthermia on tumor progression and metastasis
Original languageGerman
Pages (from-to)1043-1051
Number of pages9
JournalOnkologe
Volume16
Issue number11
DOIs
StatePublished - Nov 2010

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