Molecularly imprinted polymer for metsulfuron-methyl and its binding characteristics for sulfonylurea herbicides

Qing Zhi Zhu; Karsten Haupt; Dietmar Knopp; Reinhard Niessner

doi:10.1016/S0003-2670(01)01437-4

Molecularly imprinted polymer for metsulfuron-methyl and its binding characteristics for sulfonylurea herbicides

Qing Zhi Zhu, Karsten Haupt, Dietmar Knopp, Reinhard Niessner

Research output: Contribution to journal › Article › peer-review

139 Scopus citations

Abstract

A molecularly imprinted polymer (MIP) was prepared using metsulfuron-methyl (MSM) as the template molecule. A combinatorial protocol has been employed to optimize the polymer in terms of the kind and relative amounts of functional and cross-linking monomers. A copolymer of 2-(trifluoromethyl)acrylic acid (TFMAA) and divinylbenzene (DVB) showed the highest binding capacity for MSM. The binding characteristics of the imprinted polymers and MSM were evaluated in various solvents using equilibrium binding experiments. The results showed that the MIP binds MSM only in dichloromethane, which was used as the porogen during polymerization. Scatchard plot analysis revealed that two classes of binding sites were formed in the imprinted polymer with dissociation constants of 32.3μmoll^-1 and 1.7mmoll^-1, respectively. The specificity of the imprinted polymer was investigated by binding assays using MSM and other structurally related sulfonylurea herbicides. The results indicated that the imprinted polymer showed a marked selectivity for MSM.

Original language	English
Pages (from-to)	217-227
Number of pages	11
Journal	Analytica Chimica Acta
Volume	468
Issue number	2
DOIs	https://doi.org/10.1016/S0003-2670(01)01437-4
State	Published - 18 Sep 2002

Keywords

Herbicides
Metsulfuron-methyl
Molecular imprinting
Sulfonylurea

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10.1016/S0003-2670(01)01437-4

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title = "Molecularly imprinted polymer for metsulfuron-methyl and its binding characteristics for sulfonylurea herbicides",

abstract = "A molecularly imprinted polymer (MIP) was prepared using metsulfuron-methyl (MSM) as the template molecule. A combinatorial protocol has been employed to optimize the polymer in terms of the kind and relative amounts of functional and cross-linking monomers. A copolymer of 2-(trifluoromethyl)acrylic acid (TFMAA) and divinylbenzene (DVB) showed the highest binding capacity for MSM. The binding characteristics of the imprinted polymers and MSM were evaluated in various solvents using equilibrium binding experiments. The results showed that the MIP binds MSM only in dichloromethane, which was used as the porogen during polymerization. Scatchard plot analysis revealed that two classes of binding sites were formed in the imprinted polymer with dissociation constants of 32.3μmoll-1 and 1.7mmoll-1, respectively. The specificity of the imprinted polymer was investigated by binding assays using MSM and other structurally related sulfonylurea herbicides. The results indicated that the imprinted polymer showed a marked selectivity for MSM.",

keywords = "Herbicides, Metsulfuron-methyl, Molecular imprinting, Sulfonylurea",

author = "Zhu, {Qing Zhi} and Karsten Haupt and Dietmar Knopp and Reinhard Niessner",

note = "Funding Information: This work was supported by the Alexander von Humboldt-Foundation (Dr. Qing-Zhi Zhu) and the Fonds der Chemischen Industrie.",

year = "2002",

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doi = "10.1016/S0003-2670(01)01437-4",

language = "English",

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T1 - Molecularly imprinted polymer for metsulfuron-methyl and its binding characteristics for sulfonylurea herbicides

AU - Zhu, Qing Zhi

AU - Haupt, Karsten

AU - Knopp, Dietmar

AU - Niessner, Reinhard

N1 - Funding Information: This work was supported by the Alexander von Humboldt-Foundation (Dr. Qing-Zhi Zhu) and the Fonds der Chemischen Industrie.

PY - 2002/9/18

Y1 - 2002/9/18

N2 - A molecularly imprinted polymer (MIP) was prepared using metsulfuron-methyl (MSM) as the template molecule. A combinatorial protocol has been employed to optimize the polymer in terms of the kind and relative amounts of functional and cross-linking monomers. A copolymer of 2-(trifluoromethyl)acrylic acid (TFMAA) and divinylbenzene (DVB) showed the highest binding capacity for MSM. The binding characteristics of the imprinted polymers and MSM were evaluated in various solvents using equilibrium binding experiments. The results showed that the MIP binds MSM only in dichloromethane, which was used as the porogen during polymerization. Scatchard plot analysis revealed that two classes of binding sites were formed in the imprinted polymer with dissociation constants of 32.3μmoll-1 and 1.7mmoll-1, respectively. The specificity of the imprinted polymer was investigated by binding assays using MSM and other structurally related sulfonylurea herbicides. The results indicated that the imprinted polymer showed a marked selectivity for MSM.

AB - A molecularly imprinted polymer (MIP) was prepared using metsulfuron-methyl (MSM) as the template molecule. A combinatorial protocol has been employed to optimize the polymer in terms of the kind and relative amounts of functional and cross-linking monomers. A copolymer of 2-(trifluoromethyl)acrylic acid (TFMAA) and divinylbenzene (DVB) showed the highest binding capacity for MSM. The binding characteristics of the imprinted polymers and MSM were evaluated in various solvents using equilibrium binding experiments. The results showed that the MIP binds MSM only in dichloromethane, which was used as the porogen during polymerization. Scatchard plot analysis revealed that two classes of binding sites were formed in the imprinted polymer with dissociation constants of 32.3μmoll-1 and 1.7mmoll-1, respectively. The specificity of the imprinted polymer was investigated by binding assays using MSM and other structurally related sulfonylurea herbicides. The results indicated that the imprinted polymer showed a marked selectivity for MSM.

KW - Herbicides

KW - Metsulfuron-methyl

KW - Molecular imprinting

KW - Sulfonylurea

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U2 - 10.1016/S0003-2670(01)01437-4

DO - 10.1016/S0003-2670(01)01437-4

M3 - Article

AN - SCOPUS:0037130903

SN - 0003-2670

VL - 468

SP - 217

EP - 227

JO - Analytica Chimica Acta

JF - Analytica Chimica Acta

IS - 2

ER -

Molecularly imprinted polymer for metsulfuron-methyl and its binding characteristics for sulfonylurea herbicides

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