Molecular regulation of the hepatic bile acid uptake transporter and HBV entry receptor NTCP

Monique D. Appelman, Jochen M. Wettengel, Ulrike Protzer, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Transporters expressed by hepatocytes and enterocytes play a critical role in maintaining the enterohepatic circulation of bile acids. The sodium taurocholate cotransporting polypeptide (NTCP), exclusively expressed at the basolateral side of hepatocytes, mediates the uptake of conjugated bile acids. In conditions where bile flow is impaired (cholestasis), pharmacological inhibition of NTCP-mediated bile acid influx is suggested to reduce hepatocellular damage due to bile acid overload. Furthermore, NTCP has been shown to play an important role in hepatitis B virus (HBV) and hepatitis Delta virus (HDV) infection by functioning as receptor for viral entry into hepatocytes. This review provides a summary of current molecular insight into the regulation of NTCP expression at the plasma membrane, hepatic bile acid transport, and NTCP-mediated viral infection.

Original languageEnglish
Article number158960
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1866
Issue number8
DOIs
StatePublished - Aug 2021

Keywords

  • ASBT
  • BSEP
  • Cholestasis
  • HBV
  • HDV

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