Molecular medicine of gastric adenocarcinomas

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Upper gastrointestinal (GI) tract malignancies, including carcinomas of the esophagus, the GI junction and the stomach, are among the most common cancers worldwide. Overall survival is poor because many patients present with locally advanced and often incurable disease. This review focuses on the pathogenesis of adenocarcinomas of the stomach. It summarises recent findings on genetic predisposition to gastric cancer, in particular in relation to germline mutations in the E-cadherin gene. It also describes the molecular basis of sporadic gastric cancer, including alterations in oncogenes, tumour suppressor genes and growth factors, and discusses how these findings might be used in the clinic for improved diagnosis and therapy.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalExpert Reviews in Molecular Medicine
Volume7
Issue number17
DOIs
StatePublished - Aug 2005

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