Molecular imaging targeting peptide receptors

Margret Schottelius; Hans Jürgen Wester

doi:10.1016/j.ymeth.2009.03.012

Molecular imaging targeting peptide receptors

Margret Schottelius, Hans Jürgen Wester

Chair of Pharmaceutical Radiochemistry

Technical University of Munich

Research output: Contribution to journal › Review article › peer-review

187 Scopus citations

Abstract

Overexpressed neuropeptide receptors allow tumor visualization using e.g. radiolabeled peptidic receptor ligands and positron emission tomography (PET) or single photon emission computed tomography (SPECT). This review summarizes the development of radiolabeled probes for peptide receptor imaging since the emergence of the technology with a particular focus on peptide radiopharmaceuticals developed during the last 5 years, and highlights the different factors which are decisive during the process of tracer development and evaluation.

Original language	English
Pages (from-to)	161-177
Number of pages	17
Journal	Methods
Volume	48
Issue number	2
DOIs	https://doi.org/10.1016/j.ymeth.2009.03.012
State	Published - Jun 2009

Keywords

Cu-64
F-18
Ga-68
In-111
Molecular imaging
PET
Peptide
Positron emission tomography
Radiopharmaceutical
SPECT
Single photon emission computed tomography
Tc-99m

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10.1016/j.ymeth.2009.03.012

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title = "Molecular imaging targeting peptide receptors",

abstract = "Overexpressed neuropeptide receptors allow tumor visualization using e.g. radiolabeled peptidic receptor ligands and positron emission tomography (PET) or single photon emission computed tomography (SPECT). This review summarizes the development of radiolabeled probes for peptide receptor imaging since the emergence of the technology with a particular focus on peptide radiopharmaceuticals developed during the last 5 years, and highlights the different factors which are decisive during the process of tracer development and evaluation.",

keywords = "Cu-64, F-18, Ga-68, In-111, Molecular imaging, PET, Peptide, Positron emission tomography, Radiopharmaceutical, SPECT, Single photon emission computed tomography, Tc-99m",

author = "Margret Schottelius and Wester, {Hans J{\"u}rgen}",

year = "2009",

month = jun,

doi = "10.1016/j.ymeth.2009.03.012",

language = "English",

volume = "48",

pages = "161--177",

journal = "Methods",

issn = "1046-2023",

publisher = "Academic Press Inc.",

number = "2",

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T1 - Molecular imaging targeting peptide receptors

AU - Schottelius, Margret

AU - Wester, Hans Jürgen

PY - 2009/6

Y1 - 2009/6

N2 - Overexpressed neuropeptide receptors allow tumor visualization using e.g. radiolabeled peptidic receptor ligands and positron emission tomography (PET) or single photon emission computed tomography (SPECT). This review summarizes the development of radiolabeled probes for peptide receptor imaging since the emergence of the technology with a particular focus on peptide radiopharmaceuticals developed during the last 5 years, and highlights the different factors which are decisive during the process of tracer development and evaluation.

AB - Overexpressed neuropeptide receptors allow tumor visualization using e.g. radiolabeled peptidic receptor ligands and positron emission tomography (PET) or single photon emission computed tomography (SPECT). This review summarizes the development of radiolabeled probes for peptide receptor imaging since the emergence of the technology with a particular focus on peptide radiopharmaceuticals developed during the last 5 years, and highlights the different factors which are decisive during the process of tracer development and evaluation.

KW - Cu-64

KW - F-18

KW - Ga-68

KW - In-111

KW - Molecular imaging

KW - PET

KW - Peptide

KW - Positron emission tomography

KW - Radiopharmaceutical

KW - SPECT

KW - Single photon emission computed tomography

KW - Tc-99m

UR - http://www.scopus.com/inward/record.url?scp=66349112895&partnerID=8YFLogxK

U2 - 10.1016/j.ymeth.2009.03.012

DO - 10.1016/j.ymeth.2009.03.012

M3 - Review article

C2 - 19324088

AN - SCOPUS:66349112895

SN - 1046-2023

VL - 48

SP - 161

EP - 177

JO - Methods

JF - Methods

IS - 2

ER -

Molecular imaging targeting peptide receptors

Abstract

Keywords

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