Molecular evolution of the RNA polymerase II CTD

Rob D. Chapman, Martin Heidemann, Corinna Hintermair, Dirk Eick

Research output: Contribution to journalReview articlepeer-review

117 Scopus citations


In higher eukaryotes, an unusual C-terminal domain (CTD) is crucial to the function of RNA polymerase II in transcription. The CTD consists of multiple heptapeptide repeats; differences in the number of repeats between organisms and their degree of conservation have intrigued researchers for two decades. Here, we review the evolution of the CTD at the molecular level. Several primitive motifs have been integrated into compound heptads that can be readily amplified. The selection of phosphorylatable residues in the heptad repeat provided the opportunity for advanced gene regulation in eukaryotes. Current findings suggest that the CTD should be considered as a collection of continuous overlapping motifs as opposed to a specific functional unit defined by a heptad.

Original languageEnglish
Pages (from-to)289-296
Number of pages8
JournalTrends in Genetics
Issue number6
StatePublished - Jun 2008


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