Molecular and Genetic Basis of Pancreatic Carcinogenesis: Which Concepts are Clinically Relevant?

Ihsan Ekin Demir, Carmen Mota Reyes, Elke Demir, Helmut Friess

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Cancer is a genetically complex disease that has forced clinicians and researchers to develop targeted therapies exploiting the molecular and genetic basis of cancer. When trying to understand the molecular and genetic basis of pancreatic carcinogenesis, it has become clear that the clinically relevant aspects of the complex molecular biology behind pancreatic cancer converge on five major arms of therapy. These include: development of individual therapies based on the genomic and transcriptomic subtypes of pancreatic cancer; organoids for response prediction; enhancing the activation of immune surveillance and inhibition of immune suppression; exploiting the metabolic alterations in pancreatic cancer cells; and exploiting the fibrotic tumor microenvironment. Improved understanding and specific targeting of the molecular and genetic alterations in pancreatic cancer will be the factor that in the near future will enable a significant improvement in the therapy and prognosis of pancreatic cancer patients.

Original languageEnglish
Title of host publicationClinical Pancreatology for Practising Gastroenterologists and Surgeons
Subtitle of host publicationSecond Edition
Publisherwiley
Pages404-408
Number of pages5
ISBN (Electronic)9781119570097
ISBN (Print)9781119570073
DOIs
StatePublished - 1 Jan 2021
Externally publishedYes

Keywords

  • fibrotic tumor microenvironment
  • genetic basis
  • immune suppression
  • individual therapies
  • molecular basis
  • pancreatic cancer cells
  • pancreatic carcinogenesis
  • response prediction

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