MOF-derived cobalt nanoparticles catalyze a general synthesis of amines

Rajenahally V. Jagadeesh, Kathiravan Murugesan, Ahmad S. Alshammari, Helfried Neumann, Marga Martina Pohl, Jörg Radnik, Matthias Beller

Research output: Contribution to journalArticlepeer-review

592 Scopus citations


The development of base metal catalysts for the synthesis of pharmaceutically relevant compounds remains an important goal of chemical research. Here, we report that cobalt nanoparticles encapsulated by a graphitic shell are broadly effective reductive amination catalysts. Their convenient and practical preparation entailed template assembly of cobaltdiamine- dicarboxylic acid metal organic frameworks on carbon and subsequent pyrolysis under inert atmosphere.The resulting stable and reusable catalysts were active for synthesis of primary, secondary, tertiary, and N-methylamines (more than 140 examples).The reaction couples easily accessible carbonyl compounds (aldehydes and ketones) with ammonia, amines, or nitro compounds, and molecular hydrogen under industrially viable and scalable conditions, offering cost-effective access to numerous amines, amino acid derivatives, and more complex drug targets.

Original languageEnglish
Pages (from-to)326-332
Number of pages7
Issue number6361
StatePublished - 20 Oct 2017
Externally publishedYes


Dive into the research topics of 'MOF-derived cobalt nanoparticles catalyze a general synthesis of amines'. Together they form a unique fingerprint.

Cite this