Modulation of immune responses by the neuropeptide CGRP

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66 Scopus citations

Abstract

The peripheral nervous system is connected with lymphoid organs through sensory nerves that mediate pain reflexes and may influence immune responses through the release of neuropeptides such as calcitonin gene-related peptide (CGRP). Local and systemic levels of CGRP increase rapidly during inflammatory responses. CGRP inhibits effector functions of various immune cells and dampens inflammation by distinct pathways involving the amplification of IL-10 production and/or the induction of the transcriptional repressor inducible cAMP early repressor (ICER). Thus, available evidence suggests that, in neuro-immunological interactions, CGRP mediates a potent peptidergic anti-inflammatory pathway.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalAmino Acids
Volume45
Issue number1
DOIs
StatePublished - Jul 2013
Externally publishedYes

Keywords

  • CGRP
  • ICER
  • IL-10
  • Inflammatory disorders
  • Neuro-immunological communication
  • Sensory nerves
  • Signal transduction

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