Mixed acinar-endocrine carcinoma of the pancreas

Nobuyuki Ohike; Olca Bastürk; Günter Klöppel; Toshio Morohoshi

doi:10.1097/PCR.0b013e3181ffb18f

Mixed acinar-endocrine carcinoma of the pancreas

Nobuyuki Ohike, Olca Bastürk, Günter Klöppel, Toshio Morohoshi

Chair of Pathology

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Mixed acinar-(neuro)endocrine carcinoma (MAEC) is a malignant epithelial neoplasm of the pancreas exhibiting both acinar and (neuro)endocrine differentiation and is diagnosed when each component constitutes a significant proportion (25%-30%) of the neoplasm. Histologically, many are similar to acinar cell carcinoma (ACC), with the mixed differentiation detected by immunohistochemistry and share many clinicopathological features with ACC. Therefore, MAEC has been considered a variant of ACC. This review addresses the pathology, clinical features, and histogenesis of MAEC and its differential diagnosis.

Original language	English
Pages (from-to)	205-209
Number of pages	5
Journal	Pathology Case Reviews
Volume	15
Issue number	6
DOIs	https://doi.org/10.1097/PCR.0b013e3181ffb18f
State	Published - Nov 2010

Keywords

mixed acinar-endocrine carcinoma
pancreas
pathology

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10.1097/PCR.0b013e3181ffb18f

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title = "Mixed acinar-endocrine carcinoma of the pancreas",

abstract = "Mixed acinar-(neuro)endocrine carcinoma (MAEC) is a malignant epithelial neoplasm of the pancreas exhibiting both acinar and (neuro)endocrine differentiation and is diagnosed when each component constitutes a significant proportion (25\%-30\%) of the neoplasm. Histologically, many are similar to acinar cell carcinoma (ACC), with the mixed differentiation detected by immunohistochemistry and share many clinicopathological features with ACC. Therefore, MAEC has been considered a variant of ACC. This review addresses the pathology, clinical features, and histogenesis of MAEC and its differential diagnosis.",

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AU - Ohike, Nobuyuki

AU - Bastürk, Olca

AU - Klöppel, Günter

AU - Morohoshi, Toshio

PY - 2010/11

Y1 - 2010/11

N2 - Mixed acinar-(neuro)endocrine carcinoma (MAEC) is a malignant epithelial neoplasm of the pancreas exhibiting both acinar and (neuro)endocrine differentiation and is diagnosed when each component constitutes a significant proportion (25%-30%) of the neoplasm. Histologically, many are similar to acinar cell carcinoma (ACC), with the mixed differentiation detected by immunohistochemistry and share many clinicopathological features with ACC. Therefore, MAEC has been considered a variant of ACC. This review addresses the pathology, clinical features, and histogenesis of MAEC and its differential diagnosis.

AB - Mixed acinar-(neuro)endocrine carcinoma (MAEC) is a malignant epithelial neoplasm of the pancreas exhibiting both acinar and (neuro)endocrine differentiation and is diagnosed when each component constitutes a significant proportion (25%-30%) of the neoplasm. Histologically, many are similar to acinar cell carcinoma (ACC), with the mixed differentiation detected by immunohistochemistry and share many clinicopathological features with ACC. Therefore, MAEC has been considered a variant of ACC. This review addresses the pathology, clinical features, and histogenesis of MAEC and its differential diagnosis.

KW - mixed acinar-endocrine carcinoma

KW - pancreas

KW - pathology

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U2 - 10.1097/PCR.0b013e3181ffb18f

DO - 10.1097/PCR.0b013e3181ffb18f

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JO - Pathology Case Reviews

JF - Pathology Case Reviews

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ER -

Mixed acinar-endocrine carcinoma of the pancreas

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Keywords

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