MITOP, the mitochondrial proteome database: 2000 update

C. Scharfe, P. Zaccaria, K. Hoertnagel, M. Jaksch, T. Klopstock, M. Dembowski, R. Lill, H. Prokisch, K. D. Gerbitz, W. Neupert, H. W. Mewes, T. Meitinger

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations

Abstract

MITOP (http://www.mips.biochem.mpg.de/proj/medgen/mitop/) is a comprehensive database for genetic and functional information on both nuclear- and mitochondrial-encoded proteins and their genes. The five species files - Saccharomyces cerevisiae, Mus musculus, Caenorhabditis elegans, Neurospora crassa and Home sapiens - include annotated data derived from a variety of online resources and the literature. A wide spectrum of search facilities is given in the overlapping sections 'Gene catalogues', 'Protein catalogues', 'Homologies', 'Pathways and metabolism' and 'Human disease catalogue' including extensive references and hyperlinks to other databases. Central features are the results of various homology searches, which should facilitate the investigations into interspecies relationships. Precomputed PASTA searches using all the MITOP yeast protein entries and a list of the best human EST hits with graphical cluster alignments related to the yeast reference sequence are presented. The orthologue tables with cross-listings to all the protein entries for each species in MITOP have been expanded by adding the genomes of Rickettsia prowazeckll and Escherichia coli. To find new mitochondrial proteins the complete yeast genome has been analyzed using the MITOPROT program which identifies mitochondrial targeting sequences. The 'Human disease catalogue' contains tables with a total of 110 human diseases related to mitochondrial protein abnormalities, sorted by clinical criteria and age of onset. MITOP should contribute to the systematic genetic characterization of the mitochondrial proteome in relation to human disease.

Original languageEnglish
Pages (from-to)155-158
Number of pages4
JournalNucleic Acids Research
Volume28
Issue number1
DOIs
StatePublished - 1 Jan 2000
Externally publishedYes

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