TY - JOUR
T1 - MITOP
T2 - Database for mitochondria-related proteins, genes and diseases
AU - Scharfe, C.
AU - Zaccaria, P.
AU - Hoertnagel, K.
AU - Jaksch, M.
AU - Klopstock, T.
AU - Lill, R.
AU - Prokisch, H.
AU - Gerbitz, K. D.
AU - Mewes, H. W.
AU - Meitinger, T.
N1 - Funding Information:
We wish to thank the MIPS yeast crew for providing the yeast protein catalogues, and Kerry Baldwin-Jedele for help in preparing this manuscript. The MITOPROT program was kindly provided by Pierre Vincens and Manuel G. Claros. The MITOP project is supported by a grant from the Federal Ministry of Education, Science, Research and Technology (BMBF) and by the Ludwig-Maximilians-University, Munich.
PY - 1999/1/1
Y1 - 1999/1/1
N2 - The MITOP database http://websvr.mips.biochem. mpg.de/proj/medgen/mitop/ consolidates information on both nuclear- and mitochondrial-encoded genes and their proteins. The five species files - Saccharomyces cerevisiae, Mus musculus, Caenorhabditis elegans, Neurospora crassa and Home sapiens - include annotated data derived from a variety of online resources and the literature. A wide spectrum of search facilities is given in the interelated sections 'Gene catalogues', 'Protein catalogues', 'Homologies', 'Pathways and metabolism', and 'Human disease catalogue' including extensive references and hyperlinks for each entry. Precomputed FASTA searches using all the MITOP yeast protein entries and a list of the best EST hits with graphical cluster alignments related to the yeast reference sequence are presented. The MITOP orthologue tables with cross-listing to all the protein entries for each species in the database facilitate investigations into interspecies homology. A program (MITOPROT) is available to identify mitochondrial targeting sequences and graphical depictions of several important mitochondrial processes are included. The 'Human disease catalogue' lists a total of 101 disorders related to mitochondrial protein abnormalities, sorted by clinical criteria and age of onset.
AB - The MITOP database http://websvr.mips.biochem. mpg.de/proj/medgen/mitop/ consolidates information on both nuclear- and mitochondrial-encoded genes and their proteins. The five species files - Saccharomyces cerevisiae, Mus musculus, Caenorhabditis elegans, Neurospora crassa and Home sapiens - include annotated data derived from a variety of online resources and the literature. A wide spectrum of search facilities is given in the interelated sections 'Gene catalogues', 'Protein catalogues', 'Homologies', 'Pathways and metabolism', and 'Human disease catalogue' including extensive references and hyperlinks for each entry. Precomputed FASTA searches using all the MITOP yeast protein entries and a list of the best EST hits with graphical cluster alignments related to the yeast reference sequence are presented. The MITOP orthologue tables with cross-listing to all the protein entries for each species in the database facilitate investigations into interspecies homology. A program (MITOPROT) is available to identify mitochondrial targeting sequences and graphical depictions of several important mitochondrial processes are included. The 'Human disease catalogue' lists a total of 101 disorders related to mitochondrial protein abnormalities, sorted by clinical criteria and age of onset.
UR - http://www.scopus.com/inward/record.url?scp=0032922521&partnerID=8YFLogxK
U2 - 10.1093/nar/27.1.153
DO - 10.1093/nar/27.1.153
M3 - Short survey
C2 - 9847163
AN - SCOPUS:0032922521
SN - 0305-1048
VL - 27
SP - 153
EP - 155
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - 1
ER -