MISSBILDUNGEN DES ZNS FETALER MAUSE NACH FRAKTIONIERTER GANZKORPER RONTGENBESTRAHLUNG. TOPOGRAPHISCHE UND QUANTITATIVE MIKROMORPHOLOGISCHE CHARAKTERISIERUNG

Translated title of the contribution: Effects of fractionated whole body X irradiation on the CNS of fetal mouse. Topographic and quantitative micromorphologic characterisation

W. Schmahl, H. Kriegel, B. Ostertag

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Whole body X-irradiation of pregnant NMRI-mice between day 11-13 after conception results in a disturbed morphogenesis of the CNS: reduction of dimensions of the forebrain, and disorganisation of structure and occurrence of spherical cell arrangements (rosettes). These can be especially found in the dorsal parts of the hemispheres and have been registered qualitatively by its number and dimension in the dose range between 3 x 110 R and 3 x 120 R. A clear correlation between the number of rosettes and the reduction of thickness of the hemisphere-walls can be demonstrated. The results will be fundamental for further studies concerning the reparation processes of irradiation damage in postnatal stages.

Translated title of the contributionEffects of fractionated whole body X irradiation on the CNS of fetal mouse. Topographic and quantitative micromorphologic characterisation
Original languageGerman
Pages (from-to)630-637
Number of pages8
JournalStrahlentherapie
Volume153
Issue number9
StatePublished - 1977
Externally publishedYes

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