miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity

Shashi Kumar Gupta; Ankita Garg; Petros Avramopoulos; Stefan Engelhardt; Katrin Streckfuss-Bömeke; Sandor Batkai; Thomas Thum

doi:10.1016/j.ymthe.2018.11.004

miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity

Shashi Kumar Gupta
, Ankita Garg
, Petros Avramopoulos
, Stefan Engelhardt
, Katrin Streckfuss-Bömeke
, Sandor Batkai
, Thomas Thum

Chair of Pharmacology and Toxicology

Hannover Medical School
Technical University of Munich
Partner Site Munich Heart Alliance
University Medical Center
Hannover Medical School Campus
National Heart and Lung Institute

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Doxorubicin is known to cause dose-dependent cardiotoxicity in cancer patients. Here, Thum and colleagues show that overexpression of a pro-hypertrophic microRNA cluster, miR-212/132, can reduce the doxorubicin-induced cardiotoxic effects by reversing cardiac atrophy and apoptosis.

Original language	English
Pages (from-to)	17-28
Number of pages	12
Journal	Molecular Therapy
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/j.ymthe.2018.11.004
State	Published - 2 Jan 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

AAV
apoptosis
atrophy
cardiotoxicity
doxorubicin
microRNA

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10.1016/j.ymthe.2018.11.004

Cite this

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title = "miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity",

abstract = "Doxorubicin is known to cause dose-dependent cardiotoxicity in cancer patients. Here, Thum and colleagues show that overexpression of a pro-hypertrophic microRNA cluster, miR-212/132, can reduce the doxorubicin-induced cardiotoxic effects by reversing cardiac atrophy and apoptosis.",

keywords = "AAV, apoptosis, atrophy, cardiotoxicity, doxorubicin, microRNA",

author = "Gupta, \{Shashi Kumar\} and Ankita Garg and Petros Avramopoulos and Stefan Engelhardt and Katrin Streckfuss-B{\"o}meke and Sandor Batkai and Thomas Thum",

note = "Publisher Copyright: {\textcopyright} 2018 The American Society of Gene and Cell Therapy",

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AU - Gupta, Shashi Kumar

AU - Garg, Ankita

AU - Avramopoulos, Petros

AU - Engelhardt, Stefan

AU - Streckfuss-Bömeke, Katrin

AU - Batkai, Sandor

AU - Thum, Thomas

PY - 2019/1/2

Y1 - 2019/1/2

N2 - Doxorubicin is known to cause dose-dependent cardiotoxicity in cancer patients. Here, Thum and colleagues show that overexpression of a pro-hypertrophic microRNA cluster, miR-212/132, can reduce the doxorubicin-induced cardiotoxic effects by reversing cardiac atrophy and apoptosis.

AB - Doxorubicin is known to cause dose-dependent cardiotoxicity in cancer patients. Here, Thum and colleagues show that overexpression of a pro-hypertrophic microRNA cluster, miR-212/132, can reduce the doxorubicin-induced cardiotoxic effects by reversing cardiac atrophy and apoptosis.

KW - AAV

KW - apoptosis

KW - atrophy

KW - cardiotoxicity

KW - doxorubicin

KW - microRNA

UR - https://www.scopus.com/pages/publications/85057848645

U2 - 10.1016/j.ymthe.2018.11.004

DO - 10.1016/j.ymthe.2018.11.004

M3 - Article

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AN - SCOPUS:85057848645

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ER -

miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity

Abstract

UN SDGs

Keywords

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