miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity

Shashi Kumar Gupta; Ankita Garg; Petros Avramopoulos; Stefan Engelhardt; Katrin Streckfuss-Bömeke; Sandor Batkai; Thomas Thum

doi:10.1016/j.ymthe.2018.11.004

miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity

Shashi Kumar Gupta, Ankita Garg, Petros Avramopoulos, Stefan Engelhardt, Katrin Streckfuss-Bömeke, Sandor Batkai, Thomas Thum

Chair of Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Doxorubicin is known to cause dose-dependent cardiotoxicity in cancer patients. Here, Thum and colleagues show that overexpression of a pro-hypertrophic microRNA cluster, miR-212/132, can reduce the doxorubicin-induced cardiotoxic effects by reversing cardiac atrophy and apoptosis.

Original language	English
Pages (from-to)	17-28
Number of pages	12
Journal	Molecular Therapy
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/j.ymthe.2018.11.004
State	Published - 2 Jan 2019

Keywords

AAV
apoptosis
atrophy
cardiotoxicity
doxorubicin
microRNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ymthe.2018.11.004

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title = "miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity",

abstract = "Doxorubicin is known to cause dose-dependent cardiotoxicity in cancer patients. Here, Thum and colleagues show that overexpression of a pro-hypertrophic microRNA cluster, miR-212/132, can reduce the doxorubicin-induced cardiotoxic effects by reversing cardiac atrophy and apoptosis.",

keywords = "AAV, apoptosis, atrophy, cardiotoxicity, doxorubicin, microRNA",

author = "Gupta, \{Shashi Kumar\} and Ankita Garg and Petros Avramopoulos and Stefan Engelhardt and Katrin Streckfuss-B{\"o}meke and Sandor Batkai and Thomas Thum",

note = "Publisher Copyright: {\textcopyright} 2018 The American Society of Gene and Cell Therapy",

year = "2019",

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T1 - miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity

AU - Gupta, Shashi Kumar

AU - Garg, Ankita

AU - Avramopoulos, Petros

AU - Engelhardt, Stefan

AU - Streckfuss-Bömeke, Katrin

AU - Batkai, Sandor

AU - Thum, Thomas

PY - 2019/1/2

Y1 - 2019/1/2

N2 - Doxorubicin is known to cause dose-dependent cardiotoxicity in cancer patients. Here, Thum and colleagues show that overexpression of a pro-hypertrophic microRNA cluster, miR-212/132, can reduce the doxorubicin-induced cardiotoxic effects by reversing cardiac atrophy and apoptosis.

AB - Doxorubicin is known to cause dose-dependent cardiotoxicity in cancer patients. Here, Thum and colleagues show that overexpression of a pro-hypertrophic microRNA cluster, miR-212/132, can reduce the doxorubicin-induced cardiotoxic effects by reversing cardiac atrophy and apoptosis.

KW - AAV

KW - apoptosis

KW - atrophy

KW - cardiotoxicity

KW - doxorubicin

KW - microRNA

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U2 - 10.1016/j.ymthe.2018.11.004

DO - 10.1016/j.ymthe.2018.11.004

M3 - Article

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JO - Molecular Therapy

JF - Molecular Therapy

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ER -

miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity

Abstract

Keywords

UN SDGs

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