miR-191 modulates B-cell development and targets transcription factors E2A, Foxp1, and Egr1

Jonas Blume, Natalia Ziętara, Katrin Witzlau, Yanshan Liu, Oskar Ortiz Sanchez, Jacek Puchałka, Samantha J. Winter, Heike Kunze-Schumacher, Namita Saran, Sandra Düber, Bishnudeo Roy, Siegfried Weiss, Christoph Klein, Wolfgang Wurst, Marcin Łyszkiewicz, Andreas Krueger

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The interdependence of posttranscriptional gene regulation via miRNA and transcriptional regulatory networks in lymphocyte development is poorly understood. Here, we identified miR-191 as direct upstream modulator of a transcriptional module comprising the transcription factors Foxp1, E2A, and Egr1. Deletion as well as ectopic expression of miR-191 resulted in developmental arrest in B lineage cells, indicating that fine tuning of the combined expression levels of Foxp1, E2A, and Egr1, which in turn control somatic recombination and cytokine-driven expansion, constitutes a prerequisite for efficient B-cell development. In conclusion, we propose that miR-191 acts as a rheostat in B-cell development by fine tuning a key transcriptional program.

Original languageEnglish
Pages (from-to)121-132
Number of pages12
JournalEuropean Journal of Immunology
Volume49
Issue number1
DOIs
StatePublished - Jan 2019

Keywords

  • B cells
  • Lymphocyte development
  • Transcriptional factors
  • miR-191
  • miRNA

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