Minimal SC-ß-Cell Properties for Transplantation in Diabetic Patients

Pancreatic ß cells within the islets of Langerhans are the body’s main source for insulin. ß cells maintain glucose homeostasis through the tight control of insulin secretion and cessation in response to changes in blood glucose levels. The loss of ß cells or ß-cell dysfunction leads to the development of diabetes. Diabetes is a prevalent metabolic disease that affects populations worldwide. Considerable efforts are underway to develop therapies and treatments to combat diabetes. Transplantation of stem cell-derived ß cells (SC-ß cells) is a promising cell replacement therapy for curing diabetes. Significant advancements have been made toward generating functional SC-ß cells in laboratories. Here, we describe the essential properties of human ß cells that need to be reproduced in stem cell-derived insulin-producing cells to ensure functionality and safety.