MiniControl: Synthesis of continuous-flow microfluidics with strictly constrained control ports

Xing Huang, Tsung Yi Ho, Wenzhong Guo, Bing Li, Ulf Schlichtmann

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

25 Scopus citations


Recent advances in continuous-flow microfluidics have enabled highly integrated lab-on-a-chip biochips. These chips can execute complex biochemical applications precisely and efficiently within a tiny area, but they require a large number of control ports and the corresponding control logic to generate required pressure patterns for flow control, which, consequently, offset their advantages and prevent their wide adoption. In this paper, we propose the first synthesis flow called MiniControl, for continuous-flow microfluidic biochips (CFMBs) under strict constraints for control ports, incorporating high-level synthesis and physical design simultaneously, which has never been considered in previous work. With the maximum number of allowed control ports specified in advance, this synthesis flow generates a biochip architecture with high execution efficiency. Moreover, the overall cost of a CFMB can be reduced and the tradeoff between control logic and execution efficiency of biochemical applications can be evaluated for the first time. Experimental results demonstrate that MiniControl leads to high execution efficiency and low overall platform cost, while satisfying the given control port constraint strictly.

Original languageEnglish
Title of host publicationProceedings of the 56th Annual Design Automation Conference 2019, DAC 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781450367257
StatePublished - 2 Jun 2019
Event56th Annual Design Automation Conference, DAC 2019 - Las Vegas, United States
Duration: 2 Jun 20196 Jun 2019

Publication series

NameProceedings - Design Automation Conference
ISSN (Print)0738-100X


Conference56th Annual Design Automation Conference, DAC 2019
Country/TerritoryUnited States
CityLas Vegas


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