@inbook{b1b5e94fc8f64813bf68ccd66c4f8469,
title = "Milliliter-scale stirred tank reactors for the cultivation of microorganisms",
abstract = "This review focuses on recent developments in the field of miniaturized stirred tank bioreactors for application in high-throughput bioprocess development. Different reactor concepts and their potential for parallel bioprocess development are discussed. A detailed description of important engineering state variables, their measurement at small-scale and their implication for scale-up and scale-down of bioprocesses are given. Examples of two different parallel cultivations at small-scale are presented: one with Escherichia coli and the other one with the filamentous microorganism Streptomyces tendae. It is shown that results obtained in parallelized milliliter-scale stirred tank reactors can be scaled up to the laboratory- and/or pilot-scale in a highly reliable manner. This helps to reduce development times for bioprocesses significantly. Finally, directions for future research are presented.",
author = "Ralf Hortsch and Dirk Weuster-Botz",
year = "2010",
doi = "10.1016/S0065-2164(10)73003-3",
language = "English",
series = "Advances in Applied Microbiology",
publisher = "Academic Press Inc.",
number = "C",
pages = "61--82",
booktitle = "Advances in Applied Microbiology",
edition = "C",
}