Mild Hyperthermia Induced by Water-Filtered Infrared A Irradiation: A Potent Strategy to Foster Immune Recognition and Anti-Tumor Immune Responses in Superficial Cancers?

G. Multhoff, E. A. Repasky, Peter Vaupel

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Apart from a number of positive “physiological” effects such as an increase in local blood flow which results in an improved oxygen supply and a reversal of tumor hypoxia, a key hallmark of cancer growth which greatly impairs anti-tumor immune responses, hyperthermia (HT) also exerts beneficial effects on anti-cancer immunity. The water-filtered infrared A (wIRA) irradiation technique achieves tissue temperatures in the fever-range (tT = 39–41 °C) or mild hyperthermia levels (tT = 39–43 °C) up to tissue depths of ≈25 mm in tissues. At tissue temperatures of 39–43 °C, by fostering the reactivity of the “immunological” TME [e.g., the activity of CD8+ cytotoxic T cells, CD4+ helper T cells, dendritic cells (DC), M1 macrophages, natural killer (NK) cells, and NK-like T (NK-T) cells], while compromising immunosuppressive cells [e.g., tumor-associated M2 macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), regulatory T (Treg) cells]. Moreover, elevated temperatures resulting in mild hyperthermia induce the synthesis and release of heat-shock proteins (HSPs), and thereby augment tumor antigenicity.

Original languageEnglish
Title of host publicationWater-filtered Infrared A (wIRA) Irradiation
Subtitle of host publicationFrom Research to Clinical Settings
PublisherSpringer International Publishing
Pages129-139
Number of pages11
ISBN (Electronic)9783030928803
ISBN (Print)9783030928797
DOIs
StatePublished - 1 Jan 2022

Keywords

  • Anti-tumor immune responses
  • Heat-shock proteins
  • Immune cells
  • Immune checkpoint inhibitor
  • Immune cytokines
  • Immune evasion
  • Mild hyperthermia
  • Tumor antigenicity
  • Tumor hypoxia
  • WIRA

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