Abstract
Apart from a number of positive “physiological” effects such as an increase in local blood flow which results in an improved oxygen supply and a reversal of tumor hypoxia, a key hallmark of cancer growth which greatly impairs anti-tumor immune responses, hyperthermia (HT) also exerts beneficial effects on anti-cancer immunity. The water-filtered infrared A (wIRA) irradiation technique achieves tissue temperatures in the fever-range (tT = 39–41 °C) or mild hyperthermia levels (tT = 39–43 °C) up to tissue depths of ≈25 mm in tissues. At tissue temperatures of 39–43 °C, by fostering the reactivity of the “immunological” TME [e.g., the activity of CD8+ cytotoxic T cells, CD4+ helper T cells, dendritic cells (DC), M1 macrophages, natural killer (NK) cells, and NK-like T (NK-T) cells], while compromising immunosuppressive cells [e.g., tumor-associated M2 macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), regulatory T (Treg) cells]. Moreover, elevated temperatures resulting in mild hyperthermia induce the synthesis and release of heat-shock proteins (HSPs), and thereby augment tumor antigenicity.
Original language | English |
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Title of host publication | Water-filtered Infrared A (wIRA) Irradiation |
Subtitle of host publication | From Research to Clinical Settings |
Publisher | Springer International Publishing |
Pages | 129-139 |
Number of pages | 11 |
ISBN (Electronic) | 9783030928803 |
ISBN (Print) | 9783030928797 |
DOIs | |
State | Published - 1 Jan 2022 |
Keywords
- Anti-tumor immune responses
- Heat-shock proteins
- Immune cells
- Immune checkpoint inhibitor
- Immune cytokines
- Immune evasion
- Mild hyperthermia
- Tumor antigenicity
- Tumor hypoxia
- WIRA