Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages

Sina Bohnacker; Franziska Hartung; Fiona Henkel; Alessandro Quaranta; Johan Kolmert; Alina Priller; Minhaz Ud-Dean; Johanna Giglberger; Luisa M. Kugler; Lisa Pechtold; Sarah Yazici; Antonie Lechner; Johanna Erber; Ulrike Protzer; Paul Lingor; Percy Knolle; Adam M. Chaker; Carsten B. Schmidt-Weber; Craig E. Wheelock; Julia Esser-von Bieren

doi:10.1038/s41385-021-00482-8

Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages

Sina Bohnacker, Franziska Hartung, Fiona Henkel, Alessandro Quaranta, Johan Kolmert, Alina Priller, Minhaz Ud-Dean, Johanna Giglberger, Luisa M. Kugler, Lisa Pechtold, Sarah Yazici, Antonie Lechner, Johanna Erber, Ulrike Protzer, Paul Lingor, Percy Knolle, Adam M. Chaker, Carsten B. Schmidt-Weber, Craig E. Wheelock, Julia Esser-von Bieren

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40 Scopus citations

Original language	English
Pages (from-to)	515-524
Number of pages	10
Journal	Mucosal Immunology
Volume	15
Issue number	3
DOIs	https://doi.org/10.1038/s41385-021-00482-8
State	Published - Mar 2022

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Bohnacker, S., Hartung, F., Henkel, F., Quaranta, A., Kolmert, J., Priller, A., Ud-Dean, M., Giglberger, J., Kugler, L. M., Pechtold, L., Yazici, S., Lechner, A., Erber, J., Protzer, U., Lingor, P., Knolle, P., Chaker, A. M., Schmidt-Weber, C. B., Wheelock, C. E., & Esser-von Bieren, J. (2022). Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages. Mucosal Immunology, 15(3), 515-524. https://doi.org/10.1038/s41385-021-00482-8

@article{c849277650284155954bed65bbd68f7d,

title = "Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages",

author = "Sina Bohnacker and Franziska Hartung and Fiona Henkel and Alessandro Quaranta and Johan Kolmert and Alina Priller and Minhaz Ud-Dean and Johanna Giglberger and Kugler, {Luisa M.} and Lisa Pechtold and Sarah Yazici and Antonie Lechner and Johanna Erber and Ulrike Protzer and Paul Lingor and Percy Knolle and Chaker, {Adam M.} and Schmidt-Weber, {Carsten B.} and Wheelock, {Craig E.} and {Esser-von Bieren}, Julia",

note = "Funding Information: This study was supported by the German Research Foundation (DFG) (FOR2599, ES 471/3-1; ES 471/2-3), a Helmholtz Young Investigator grant (VH-NG-1331) to J.E.v.B. and grants by the Swedish Heart Lung Foundation HLF 20210519, HLF 20200693 to C.E.W., the German University Medicine network NUM via project B-FAST, the For-COVID consortium funded by the state of Bavaria and the Project “Virological and immunological determinants of COVID-19 pathogenesis – lessons to get prepared for future pandemics (KA1-Co-02 “COVIPA”)”, a grant from the Helmholtz Association{\textquoteright}s Initiative and Networking Fund to UP and PK. C.S.-W. receives grant support by the German Center for Lung Research (DZL; 82DZL00302). Open Access funding enabled and organized by Projekt DEAL. Funding Information: We would like to thank members of the SeCoMRI study group, Sonja Schindela and staff of the histology laboratory of the Dermatology Department, Klinikum rechts der Isar and of the Helmholtz Center Munich Genomics platform for technical support. Funding Information: C. B. S.-W. received grant support from Allergopharma, PLS Design, as well as Zeller AG; and received speaker honoraria from Allergopharma. U. Protzer is co-funder, board member and share holder of SCG Cell Therapy Inc. and serves as ad hoc advisor for Sanofi-Pasteur, BioNTech, Janssen and Swedish Orphan Biovitrum concerning COVID-19. The rest of the authors declare that they have no relevant conflicts of interest related to this work. ",

year = "2022",

month = mar,

doi = "10.1038/s41385-021-00482-8",

language = "English",

volume = "15",

pages = "515--524",

journal = "Mucosal Immunology",

issn = "1933-0219",

publisher = "Elsevier B.V.",

number = "3",

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Bohnacker, S, Hartung, F, Henkel, F, Quaranta, A, Kolmert, J, Priller, A, Ud-Dean, M, Giglberger, J, Kugler, LM, Pechtold, L, Yazici, S, Lechner, A, Erber, J, Protzer, U , Lingor, P , Knolle, P, Chaker, AM, Schmidt-Weber, CB, Wheelock, CE & Esser-von Bieren, J 2022, 'Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages', Mucosal Immunology, vol. 15, no. 3, pp. 515-524. https://doi.org/10.1038/s41385-021-00482-8

TY - JOUR

T1 - Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages

AU - Bohnacker, Sina

AU - Hartung, Franziska

AU - Henkel, Fiona

AU - Quaranta, Alessandro

AU - Kolmert, Johan

AU - Priller, Alina

AU - Ud-Dean, Minhaz

AU - Giglberger, Johanna

AU - Kugler, Luisa M.

AU - Pechtold, Lisa

AU - Yazici, Sarah

AU - Lechner, Antonie

AU - Erber, Johanna

AU - Protzer, Ulrike

AU - Lingor, Paul

AU - Knolle, Percy

AU - Chaker, Adam M.

AU - Schmidt-Weber, Carsten B.

AU - Wheelock, Craig E.

AU - Esser-von Bieren, Julia

N1 - Funding Information: This study was supported by the German Research Foundation (DFG) (FOR2599, ES 471/3-1; ES 471/2-3), a Helmholtz Young Investigator grant (VH-NG-1331) to J.E.v.B. and grants by the Swedish Heart Lung Foundation HLF 20210519, HLF 20200693 to C.E.W., the German University Medicine network NUM via project B-FAST, the For-COVID consortium funded by the state of Bavaria and the Project “Virological and immunological determinants of COVID-19 pathogenesis – lessons to get prepared for future pandemics (KA1-Co-02 “COVIPA”)”, a grant from the Helmholtz Association’s Initiative and Networking Fund to UP and PK. C.S.-W. receives grant support by the German Center for Lung Research (DZL; 82DZL00302). Open Access funding enabled and organized by Projekt DEAL. Funding Information: We would like to thank members of the SeCoMRI study group, Sonja Schindela and staff of the histology laboratory of the Dermatology Department, Klinikum rechts der Isar and of the Helmholtz Center Munich Genomics platform for technical support. Funding Information: C. B. S.-W. received grant support from Allergopharma, PLS Design, as well as Zeller AG; and received speaker honoraria from Allergopharma. U. Protzer is co-funder, board member and share holder of SCG Cell Therapy Inc. and serves as ad hoc advisor for Sanofi-Pasteur, BioNTech, Janssen and Swedish Orphan Biovitrum concerning COVID-19. The rest of the authors declare that they have no relevant conflicts of interest related to this work.

PY - 2022/3

Y1 - 2022/3

UR - http://www.scopus.com/inward/record.url?scp=85126194658&partnerID=8YFLogxK

U2 - 10.1038/s41385-021-00482-8

DO - 10.1038/s41385-021-00482-8

M3 - Article

C2 - 35288643

AN - SCOPUS:85126194658

SN - 1933-0219

VL - 15

SP - 515

EP - 524

JO - Mucosal Immunology

JF - Mucosal Immunology

IS - 3

ER -

Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages

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