Mikrosensor-gesteuerte Ruckkopplungs-Bioaktuatoren auf Halbleiterbasis zur biophysikalischen Krebsbehandlung

Translated title of the contribution: Microsensor-based feedback bioactuators on semiconductor basis for biophysical cancer treatment

Bernhard Wolf, Michael Kraus

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Acidic microenvironmental conditions combined with large hypoxic areas are ubiquitous hallmarks of most solid tumors. They result from a poorly organized vascularization and a deviant energy metabolism. There is convincing evidence supporting the hypothesis that such physico-chemical conditions promote the micro-evolution of malignant cells, inhibit the cellular immune response, and favor tumor cell invasion. In agreement with published data, our cell biological analyses and computer simulations indicate that treatment schemes which restore a tumor microenvironment reflecting that one found in normal tissues might improve the efficiency of immunotherapies and classical methods for cancer treatment. We suggest that the tumor microenvironment could be effectively monitored and manipulated by means of silicon-based feedback bioactuators which are controlled by intregrated microsensors. In principle, miniaturized bioactuators can be implanted directly at the sites of inoperable tumors and metastases where they function as a 'pH clamp' and thereby can reconstitute normal physico-chemical conditions. Drug application could be precisely controlled by an integrated microprocessor. Our paper summarizes the current state of development of microsensor-based feedback bioactuators and outlines possible applications in biophysical cancer treatment.

Translated title of the contributionMicrosensor-based feedback bioactuators on semiconductor basis for biophysical cancer treatment
Original languageGerman
Pages (from-to)444-451
Number of pages8
Issue number10
StatePublished - 1997
Externally publishedYes


Dive into the research topics of 'Microsensor-based feedback bioactuators on semiconductor basis for biophysical cancer treatment'. Together they form a unique fingerprint.

Cite this