TY - JOUR
T1 - Midbrain dopaminergic neurons are protected from radical induced damage by GDF-5 application
AU - Lingor, P.
AU - Unsicker, K.
AU - Krieglstein, K.
PY - 1999
Y1 - 1999
N2 - Embryonic day 14 rat midbrain cultures were kept for 7 days in vitro and then intoxicated with radical donors iron and sodium-nitroprusside for 24 h. Tyrosine-hydroxylase positive neurons in cultures which were additionally treated with growth/differentiation factor-5 (GDF-5) survived to a significantly higher percentage as compared to sister cultures without factor supplementation. Since the degeneration of TH positive cells is a key feature in Parkinson's disease, GDF-5 might be a putative therapeutical agent for this disorder.
AB - Embryonic day 14 rat midbrain cultures were kept for 7 days in vitro and then intoxicated with radical donors iron and sodium-nitroprusside for 24 h. Tyrosine-hydroxylase positive neurons in cultures which were additionally treated with growth/differentiation factor-5 (GDF-5) survived to a significantly higher percentage as compared to sister cultures without factor supplementation. Since the degeneration of TH positive cells is a key feature in Parkinson's disease, GDF-5 might be a putative therapeutical agent for this disorder.
KW - Dopaminergic neurons
KW - Fe
KW - NO
KW - Neurotrophic factors
KW - Parkinson's disease (PD)
UR - http://www.scopus.com/inward/record.url?scp=0032983894&partnerID=8YFLogxK
U2 - 10.1007/s007020050146
DO - 10.1007/s007020050146
M3 - Article
C2 - 10226934
AN - SCOPUS:0032983894
SN - 0300-9564
VL - 106
SP - 139
EP - 144
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
IS - 2
ER -
