MicroRNAs as therapeutic targets in cardiovascular disease

Bernhard Laggerbauer, Stefan Engelhardt

Research output: Contribution to journalReview articlepeer-review

80 Scopus citations

Abstract

The discovery of microRNAs and their role in diseases was a breakthrough that inspired research into microRNAs as drug targets. Cardiovascular diseases are an area in which limitations of conventional pharmacotherapy are highly apparent and where microRNA-based drugs have appreciably progressed into preclinical and clinical testing. In this Review, we summarize the current state of microRNAs as therapeutic targets in the cardiovascular system. We report recent advances in the identification and characterization of microRNAs, their manipulation and clinical translation, and discuss challenges and perspectives toward clinical application.

Original languageEnglish
Article numbere159179
JournalJournal of Clinical Investigation
Volume132
Issue number11
DOIs
StatePublished - 1 Jun 2022

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