Micron-Scale NV-NMR Spectroscopy with Signal Amplification by Reversible Exchange

Nithya Arunkumar; Dominik B. Bucher; Matthew J. Turner; Patrick Tomhon; David Glenn; Sören Lehmkuhl; Mikhail D. Lukin; Hongkun Park; Matthew S. Rosen; Thomas Theis; Ronald L. Walsworth

doi:10.1103/PRXQuantum.2.010305

Micron-Scale NV-NMR Spectroscopy with Signal Amplification by Reversible Exchange

Nithya Arunkumar, Dominik B. Bucher, Matthew J. Turner, Patrick Tomhon, David Glenn, Sören Lehmkuhl, Mikhail D. Lukin, Hongkun Park, Matthew S. Rosen, Thomas Theis, Ronald L. Walsworth

Chair of Inorganic Chemistry (2008 — 2022)

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Optically probed nitrogen-vacancy (NV)) quantum defects in diamond can detect nuclear magnetic resonance (NMR) signals with high-spectral resolution from micron-scale sample volumes of about 10 pl. However, a key challenge for NV-NMR spectroscopy is detecting samples at millimolar concentrations. Here we demonstrate an increase in NV-NMR proton concentration sensitivity by hyperpolarizing sample proton spins to about 0.5% through signal amplification by reversible exchange (SABRE), enabling micron-scale NMR spectroscopy of small-molecule sample concentrations as low as 1 mM in picoliter volumes. The SABRE-enhanced NV-NMR technique may enable detection and chemical analysis of low-concentration molecules and their dynamics in complex micron-scale systems such as single cells.

Original language	English
Article number	010305
Journal	PRX Quantum
Volume	2
Issue number	1
DOIs	https://doi.org/10.1103/PRXQuantum.2.010305
State	Published - Jan 2021

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abstract = "Optically probed nitrogen-vacancy (NV)) quantum defects in diamond can detect nuclear magnetic resonance (NMR) signals with high-spectral resolution from micron-scale sample volumes of about 10 pl. However, a key challenge for NV-NMR spectroscopy is detecting samples at millimolar concentrations. Here we demonstrate an increase in NV-NMR proton concentration sensitivity by hyperpolarizing sample proton spins to about 0.5% through signal amplification by reversible exchange (SABRE), enabling micron-scale NMR spectroscopy of small-molecule sample concentrations as low as 1 mM in picoliter volumes. The SABRE-enhanced NV-NMR technique may enable detection and chemical analysis of low-concentration molecules and their dynamics in complex micron-scale systems such as single cells.",

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AU - Arunkumar, Nithya

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AU - Turner, Matthew J.

AU - Tomhon, Patrick

AU - Glenn, David

AU - Lehmkuhl, Sören

AU - Lukin, Mikhail D.

AU - Park, Hongkun

AU - Rosen, Matthew S.

AU - Theis, Thomas

AU - Walsworth, Ronald L.

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AB - Optically probed nitrogen-vacancy (NV)) quantum defects in diamond can detect nuclear magnetic resonance (NMR) signals with high-spectral resolution from micron-scale sample volumes of about 10 pl. However, a key challenge for NV-NMR spectroscopy is detecting samples at millimolar concentrations. Here we demonstrate an increase in NV-NMR proton concentration sensitivity by hyperpolarizing sample proton spins to about 0.5% through signal amplification by reversible exchange (SABRE), enabling micron-scale NMR spectroscopy of small-molecule sample concentrations as low as 1 mM in picoliter volumes. The SABRE-enhanced NV-NMR technique may enable detection and chemical analysis of low-concentration molecules and their dynamics in complex micron-scale systems such as single cells.

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Micron-Scale NV-NMR Spectroscopy with Signal Amplification by Reversible Exchange

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