Microbial reduction of N-allylhydroxylamines to N-allyl-amines using clostridia

H. Braun, F. P. Schmidtchen, A. Schneider, H. Simon

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Chiral organic hydroxylamines can be reduced to the corresponding chiral amines in high yield without racemization using resting cells of C. kluyveri, C. tyrobutyricum or C. thermoaceticum in aqueous buffer with H2 CO or Na-formate as reducing agents. These reduction systems are unselective with respect to substrate chirality and leave CC double bonds and aliphatic carbon-chlorine bonds unharmed. Considering the product inhibition by the amines optimized reaction conditions were elaborated to employ formate, and 60-120 mg wet packed cells of C. thermoaceticum for reducing 0.1 mmol substrate in 1 hour.

Original languageEnglish
Pages (from-to)3329-3334
Number of pages6
JournalTetrahedron
Volume47
Issue number20-21
DOIs
StatePublished - 1991

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