Microarray-based identification of differentially expressed growth- and metastasis-associated genes in pancreatic cancer

H. Friess; J. Ding; J. Kleeff; L. Fenkell; J. A. Rosinski; A. Guweidhi; J. F. Reidhaar-Olson; M. Korc; J. Hammer; M. W. Büchler

doi:10.1007/s00018-003-3036-5

Microarray-based identification of differentially expressed growth- and metastasis-associated genes in pancreatic cancer

H. Friess
, J. Ding
, J. Kleeff
, L. Fenkell
, J. A. Rosinski
, A. Guweidhi
, J. F. Reidhaar-Olson
, M. Korc
, J. Hammer
, M. W. Büchler

Heidelberg University
Hoffmann-La Roche Inc.
University of California, Irvine

Research output: Contribution to journal › Article › peer-review

132 Scopus citations

Abstract

Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis. To improve diagnosis and treatment, key mechanisms of deregulated molecular functions have to be identified. Using microarray analysis, the expression patterns of 5600 human genes were assessed in PDAC by comparison with the normal pancreas and chronic pancreatitis (CP). The expression of 467 of 5600 genes was increased in PDAC in comparison to the normal pancreas, and the expression of 120 of these genes was not increased in CP. In addition, 341 of 5600 genes were expressed at decreased levels in PDAC tissues, of which 96 were decreased in comparison to both normal and CP tissues. Thus, a total of 808 of 5600 human genes were differentially expressed in pancreatic cancer. The identification of a large panel of altered genes in PDAC will stimulate additional studies that will lead to improved understanding of the molecular mechanisms underlying pancreatic malignant growth.

Original language	English
Pages (from-to)	1180-1199
Number of pages	20
Journal	Cellular and Molecular Life Sciences
Volume	60
Issue number	6
DOIs	https://doi.org/10.1007/s00018-003-3036-5
State	Published - 1 Jun 2003
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chronic pancreatitis
DNA array
Gene transcription
Pancreatic cancer
TGF-β

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10.1007/s00018-003-3036-5

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@article{52287ccac8d747c981cbf1386f3f5049,

title = "Microarray-based identification of differentially expressed growth- and metastasis-associated genes in pancreatic cancer",

abstract = "Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis. To improve diagnosis and treatment, key mechanisms of deregulated molecular functions have to be identified. Using microarray analysis, the expression patterns of 5600 human genes were assessed in PDAC by comparison with the normal pancreas and chronic pancreatitis (CP). The expression of 467 of 5600 genes was increased in PDAC in comparison to the normal pancreas, and the expression of 120 of these genes was not increased in CP. In addition, 341 of 5600 genes were expressed at decreased levels in PDAC tissues, of which 96 were decreased in comparison to both normal and CP tissues. Thus, a total of 808 of 5600 human genes were differentially expressed in pancreatic cancer. The identification of a large panel of altered genes in PDAC will stimulate additional studies that will lead to improved understanding of the molecular mechanisms underlying pancreatic malignant growth.",

keywords = "Chronic pancreatitis, DNA array, Gene transcription, Pancreatic cancer, TGF-β",

author = "H. Friess and J. Ding and J. Kleeff and L. Fenkell and Rosinski, \{J. A.\} and A. Guweidhi and Reidhaar-Olson, \{J. F.\} and M. Korc and J. Hammer and B{\"u}chler, \{M. W.\}",

year = "2003",

month = jun,

day = "1",

doi = "10.1007/s00018-003-3036-5",

language = "English",

volume = "60",

pages = "1180--1199",

journal = "Cellular and Molecular Life Sciences",

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TY - JOUR

T1 - Microarray-based identification of differentially expressed growth- and metastasis-associated genes in pancreatic cancer

AU - Friess, H.

AU - Ding, J.

AU - Kleeff, J.

AU - Fenkell, L.

AU - Rosinski, J. A.

AU - Guweidhi, A.

AU - Reidhaar-Olson, J. F.

AU - Korc, M.

AU - Hammer, J.

AU - Büchler, M. W.

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis. To improve diagnosis and treatment, key mechanisms of deregulated molecular functions have to be identified. Using microarray analysis, the expression patterns of 5600 human genes were assessed in PDAC by comparison with the normal pancreas and chronic pancreatitis (CP). The expression of 467 of 5600 genes was increased in PDAC in comparison to the normal pancreas, and the expression of 120 of these genes was not increased in CP. In addition, 341 of 5600 genes were expressed at decreased levels in PDAC tissues, of which 96 were decreased in comparison to both normal and CP tissues. Thus, a total of 808 of 5600 human genes were differentially expressed in pancreatic cancer. The identification of a large panel of altered genes in PDAC will stimulate additional studies that will lead to improved understanding of the molecular mechanisms underlying pancreatic malignant growth.

AB - Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis. To improve diagnosis and treatment, key mechanisms of deregulated molecular functions have to be identified. Using microarray analysis, the expression patterns of 5600 human genes were assessed in PDAC by comparison with the normal pancreas and chronic pancreatitis (CP). The expression of 467 of 5600 genes was increased in PDAC in comparison to the normal pancreas, and the expression of 120 of these genes was not increased in CP. In addition, 341 of 5600 genes were expressed at decreased levels in PDAC tissues, of which 96 were decreased in comparison to both normal and CP tissues. Thus, a total of 808 of 5600 human genes were differentially expressed in pancreatic cancer. The identification of a large panel of altered genes in PDAC will stimulate additional studies that will lead to improved understanding of the molecular mechanisms underlying pancreatic malignant growth.

KW - Chronic pancreatitis

KW - DNA array

KW - Gene transcription

KW - Pancreatic cancer

KW - TGF-β

UR - https://www.scopus.com/pages/publications/0038047893

U2 - 10.1007/s00018-003-3036-5

DO - 10.1007/s00018-003-3036-5

M3 - Article

C2 - 12861384

AN - SCOPUS:0038047893

SN - 1420-682X

VL - 60

SP - 1180

EP - 1199

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

IS - 6

ER -

Microarray-based identification of differentially expressed growth- and metastasis-associated genes in pancreatic cancer

Abstract

UN SDGs

Keywords

Access to Document

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