Microarray-based gene expression profiling in pancreatic ductal carcinoma: Status quo and perspectives

Robert Grützmann; Hans Detlev Saeger; Jutta Lüttges; Hans Konrad Schackert; Holger Kalthoff; Günter Klöppel; Christian Pilarsky

Microarray-based gene expression profiling in pancreatic ductal carcinoma: Status quo and perspectives

Robert Grützmann, Hans Detlev Saeger, Jutta Lüttges, Hans Konrad Schackert, Holger Kalthoff, Günter Klöppel, Christian Pilarsky

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Background: Pancreatic ductal adenocarcinoma has an extremely poor prognosis. To improve the prognosis, novel molecular markers and targets for earlier diagnosis and adjuvant and/or neoadjuvant treatment need to be identified. One of the key techniques that has been developed to achieve this goal is DNA microarray profiling, which is used to identify the mechanisms of deregulated molecular functions in pancreatic carcinoma cells. Objective: As several studies using microarrays have already been published, this review attempts to compare published data and crossvalidate the results. In addition, the applied techniques are discussed.

Original language	English
Pages (from-to)	401-413
Number of pages	13
Journal	International Journal of Colorectal Disease
Volume	19
Issue number	5
State	Published - Sep 2004
Externally published	Yes

Keywords

Gene expression profiling
Microarray
Pancreatic cancer
Pancreatic ductal carcinoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Microarray-based gene expression profiling in pancreatic ductal carcinoma: Status quo and perspectives",

abstract = "Background: Pancreatic ductal adenocarcinoma has an extremely poor prognosis. To improve the prognosis, novel molecular markers and targets for earlier diagnosis and adjuvant and/or neoadjuvant treatment need to be identified. One of the key techniques that has been developed to achieve this goal is DNA microarray profiling, which is used to identify the mechanisms of deregulated molecular functions in pancreatic carcinoma cells. Objective: As several studies using microarrays have already been published, this review attempts to compare published data and crossvalidate the results. In addition, the applied techniques are discussed.",

keywords = "Gene expression profiling, Microarray, Pancreatic cancer, Pancreatic ductal carcinoma",

author = "Robert Gr{\"u}tzmann and Saeger, {Hans Detlev} and Jutta L{\"u}ttges and Schackert, {Hans Konrad} and Holger Kalthoff and G{\"u}nter Kl{\"o}ppel and Christian Pilarsky",

note = "Funding Information: Acknowledgements The authors would like to thank Grit Faul-mann and Kay Dege for critical reading of the manuscript, as well as Alfred E. Neumann, whose comments were always appreciated. This paper was supported by the Deutsche Krebshilfe e.V. (70– 2937-SaI).",

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month = sep,

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T1 - Microarray-based gene expression profiling in pancreatic ductal carcinoma

T2 - Status quo and perspectives

AU - Grützmann, Robert

AU - Saeger, Hans Detlev

AU - Lüttges, Jutta

AU - Schackert, Hans Konrad

AU - Kalthoff, Holger

AU - Klöppel, Günter

AU - Pilarsky, Christian

N1 - Funding Information: Acknowledgements The authors would like to thank Grit Faul-mann and Kay Dege for critical reading of the manuscript, as well as Alfred E. Neumann, whose comments were always appreciated. This paper was supported by the Deutsche Krebshilfe e.V. (70– 2937-SaI).

PY - 2004/9

Y1 - 2004/9

N2 - Background: Pancreatic ductal adenocarcinoma has an extremely poor prognosis. To improve the prognosis, novel molecular markers and targets for earlier diagnosis and adjuvant and/or neoadjuvant treatment need to be identified. One of the key techniques that has been developed to achieve this goal is DNA microarray profiling, which is used to identify the mechanisms of deregulated molecular functions in pancreatic carcinoma cells. Objective: As several studies using microarrays have already been published, this review attempts to compare published data and crossvalidate the results. In addition, the applied techniques are discussed.

AB - Background: Pancreatic ductal adenocarcinoma has an extremely poor prognosis. To improve the prognosis, novel molecular markers and targets for earlier diagnosis and adjuvant and/or neoadjuvant treatment need to be identified. One of the key techniques that has been developed to achieve this goal is DNA microarray profiling, which is used to identify the mechanisms of deregulated molecular functions in pancreatic carcinoma cells. Objective: As several studies using microarrays have already been published, this review attempts to compare published data and crossvalidate the results. In addition, the applied techniques are discussed.

KW - Gene expression profiling

KW - Microarray

KW - Pancreatic cancer

KW - Pancreatic ductal carcinoma

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M3 - Review article

C2 - 14745573

AN - SCOPUS:4444327778

SN - 0179-1958

VL - 19

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JO - International Journal of Colorectal Disease

JF - International Journal of Colorectal Disease

IS - 5

ER -

Microarray-based gene expression profiling in pancreatic ductal carcinoma: Status quo and perspectives

Abstract

Keywords

UN SDGs

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