MIB-1, AgNOR and DNA distribution parameters and their prognostic value in neuroendocrine tumours of the lung

Uta Jütting; Peter Gais; Karsten Rodenacker; Joachim Böhm; Heinz Höfler

doi:10.5566/ias.v19.p39-43

MIB-1, AgNOR and DNA distribution parameters and their prognostic value in neuroendocrine tumours of the lung

Uta Jütting, Peter Gais, Karsten Rodenacker, Joachim Böhm, Heinz Höfler

TUM Emeriti of Excellence

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

One of the most important questions in clinical routine is to find out patients with good or worse prognosis to apply an optimal therapy scheme for each patient. In this study 58 patients with different neuroendocrine tumours of the lung were investigated. Histological sections were prepared with different stainings (MIB-1, AgNOR, Feulgen). By means of high resolution image cytometry stereological parameters were derived which are indicators for proliferation, ploidy and kinetics of the tumours. Cox regression analysis was calculated to test the significance of the parameters with regard to prognosis. The best parameter was MIB-1 which can easily be applied as a clinical standard staining and measurement.

Original language	English
Pages (from-to)	39-43
Number of pages	5
Journal	Image Analysis and Stereology
Volume	19
Issue number	1
DOIs	https://doi.org/10.5566/ias.v19.p39-43
State	Published - 2000

Keywords

AgNOR
Carcinoid
DNA distribution
Image analysis
MIB-1
Neuroendocrine lung tumours
Prognosis
Small cell carcinoma

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abstract = "One of the most important questions in clinical routine is to find out patients with good or worse prognosis to apply an optimal therapy scheme for each patient. In this study 58 patients with different neuroendocrine tumours of the lung were investigated. Histological sections were prepared with different stainings (MIB-1, AgNOR, Feulgen). By means of high resolution image cytometry stereological parameters were derived which are indicators for proliferation, ploidy and kinetics of the tumours. Cox regression analysis was calculated to test the significance of the parameters with regard to prognosis. The best parameter was MIB-1 which can easily be applied as a clinical standard staining and measurement.",

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AU - Gais, Peter

AU - Rodenacker, Karsten

AU - Böhm, Joachim

AU - Höfler, Heinz

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MIB-1, AgNOR and DNA distribution parameters and their prognostic value in neuroendocrine tumours of the lung

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Keywords

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