Methylphenidate enhances both intracortical inhibition and facilitation in healthy adults

Janbernd Kirschner; G. H. Moll; U. M. Fietzek; H. Heinrich; V. Mall; S. Berweck; F. Heinen; A. Rothenberger

doi:10.1055/s-2003-39049

Methylphenidate enhances both intracortical inhibition and facilitation in healthy adults

Janbernd Kirschner, G. H. Moll, U. M. Fietzek, H. Heinrich, V. Mall, S. Berweck, F. Heinen, A. Rothenberger

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Transcranial magnetic stimulation was used to investigate the effect of the psychostimulant drug methylphenidate (MPH) on motor cortex excitability in healthy adults (n = 12) in a placebo-controlled, crossover design study. MPH caused an enhancement of intracortical inhibition as well as intracortical facilitation. Enhancement of both of these TMS parameters was unexpected and suggests that MPH exerts its action on the motor cortex not only through the dopaminergic neurotransmitter system.

Original language	English
Pages (from-to)	79-82
Number of pages	4
Journal	Pharmacopsychiatry
Volume	36
Issue number	2
DOIs	https://doi.org/10.1055/s-2003-39049
State	Published - 2003
Externally published	Yes

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abstract = "Transcranial magnetic stimulation was used to investigate the effect of the psychostimulant drug methylphenidate (MPH) on motor cortex excitability in healthy adults (n = 12) in a placebo-controlled, crossover design study. MPH caused an enhancement of intracortical inhibition as well as intracortical facilitation. Enhancement of both of these TMS parameters was unexpected and suggests that MPH exerts its action on the motor cortex not only through the dopaminergic neurotransmitter system.",

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AU - Kirschner, Janbernd

AU - Moll, G. H.

AU - Fietzek, U. M.

AU - Heinrich, H.

AU - Mall, V.

AU - Berweck, S.

AU - Heinen, F.

AU - Rothenberger, A.

PY - 2003

Y1 - 2003

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AB - Transcranial magnetic stimulation was used to investigate the effect of the psychostimulant drug methylphenidate (MPH) on motor cortex excitability in healthy adults (n = 12) in a placebo-controlled, crossover design study. MPH caused an enhancement of intracortical inhibition as well as intracortical facilitation. Enhancement of both of these TMS parameters was unexpected and suggests that MPH exerts its action on the motor cortex not only through the dopaminergic neurotransmitter system.

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ER -

Methylphenidate enhances both intracortical inhibition and facilitation in healthy adults

Abstract

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