Methylmercury chloride induces learning deficits in prenatally treated Rats

H. R. Müsch, M. Bornhausen, H. Kriegel, H. Greim

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Methylmercury chloride (MMC) was given to pregnant rats on the 6th, 7th, 8th, and 9th day after conception in doses of 0.05 and 2.0 mg/kg/day. The female offspring of these animals were tested 90 days after birth for learning ability using operant conditioning procedures. The rats were kept at 90% of their normal body weight and trained in a lever-box to press a bar in order to obtain a food pellet. Significant differences in the acquisition speed became apparent when the ratio of bar presses to reward was increased in a classical contingency of differential reinforcement of high rates even at MMC-doses of 4 × 0.05 mg/kg. These differences were not found in the general motility level nor in motor coordination.

Original languageEnglish
Pages (from-to)103-108
Number of pages6
JournalArchives of Toxicology
Issue number2
StatePublished - Jun 1978
Externally publishedYes


  • Learning
  • Methylmercury chloride
  • Operant behaviour
  • Prenatal treatment
  • Rats


Dive into the research topics of 'Methylmercury chloride induces learning deficits in prenatally treated Rats'. Together they form a unique fingerprint.

Cite this