Methods in Toxicology

Rüdiger Bartsch; Ilse Dore Adler; Ulrich Andrae; Günter Speit; Stephan Madle; Peter Kasper; Ulrike Pabel; Michael G. Bird; Kurt Ulm; Laura Suter-Dick; Thomas Singer; György Csanády

doi:10.1002/9780470868959.ch4

Methods in Toxicology

Rüdiger Bartsch
, Ilse Dore Adler
, Ulrich Andrae
, Günter Speit
, Stephan Madle
, Peter Kasper
, Ulrike Pabel
, Michael G. Bird
, Kurt Ulm
, Laura Suter-Dick
, Thomas Singer
, György Csanády

Institute of AI and Informatics in Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Animal tests are necessary to discover possible adverse effects of chemical substances and pharmaceuticals to humans. Certain in vivo tests are, therefore, required by regulatory agencies and must be carried out according to internationally recognized test guidelines by qualified test laboratories.

Original language	English
Title of host publication	Toxicology and Risk Assessment
Subtitle of host publication	A Comprehensive Introduction
Publisher	John Wiley & Sons, Ltd
Pages	353-477
Number of pages	125
ISBN (Print)	9780470868935
DOIs	https://doi.org/10.1002/9780470868959.ch4
State	Published - 8 Feb 2008

Keywords

Common unimodal distribution
Corresponding mortality rate
Gene- and protein-expression measurements
Mammalian cell mutagenicity tests
Maximum tolerated dose (MTD)
Mechanistically plausible expectation
Mouse fibroblast cell lines
Organ-specific genotoxic events
Time- and dose-effect relationship
Xenobiotic-metabolizing enzymes

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10.1002/9780470868959.ch4

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keywords = "Common unimodal distribution, Corresponding mortality rate, Gene- and protein-expression measurements, Mammalian cell mutagenicity tests, Maximum tolerated dose (MTD), Mechanistically plausible expectation, Mouse fibroblast cell lines, Organ-specific genotoxic events, Time- and dose-effect relationship, Xenobiotic-metabolizing enzymes",

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T1 - Methods in Toxicology

AU - Bartsch, Rüdiger

AU - Adler, Ilse Dore

AU - Andrae, Ulrich

AU - Speit, Günter

AU - Madle, Stephan

AU - Kasper, Peter

AU - Pabel, Ulrike

AU - Bird, Michael G.

AU - Ulm, Kurt

AU - Suter-Dick, Laura

AU - Singer, Thomas

AU - Csanády, György

PY - 2008/2/8

Y1 - 2008/2/8

N2 - Animal tests are necessary to discover possible adverse effects of chemical substances and pharmaceuticals to humans. Certain in vivo tests are, therefore, required by regulatory agencies and must be carried out according to internationally recognized test guidelines by qualified test laboratories.

AB - Animal tests are necessary to discover possible adverse effects of chemical substances and pharmaceuticals to humans. Certain in vivo tests are, therefore, required by regulatory agencies and must be carried out according to internationally recognized test guidelines by qualified test laboratories.

KW - Common unimodal distribution

KW - Corresponding mortality rate

KW - Gene- and protein-expression measurements

KW - Mammalian cell mutagenicity tests

KW - Maximum tolerated dose (MTD)

KW - Mechanistically plausible expectation

KW - Mouse fibroblast cell lines

KW - Organ-specific genotoxic events

KW - Time- and dose-effect relationship

KW - Xenobiotic-metabolizing enzymes

UR - https://www.scopus.com/pages/publications/84889364453

U2 - 10.1002/9780470868959.ch4

DO - 10.1002/9780470868959.ch4

M3 - Chapter

AN - SCOPUS:84889364453

SN - 9780470868935

SP - 353

EP - 477

BT - Toxicology and Risk Assessment

PB - John Wiley & Sons, Ltd

ER -

Methods in Toxicology

Abstract

Keywords

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