Metabolic Precision Medicines: Curing POMC Deficiency

Timo D. Müller; Matthias H. Tschöp; Stephen O'Rahilly

doi:10.1016/j.cmet.2016.07.006

Metabolic Precision Medicines: Curing POMC Deficiency

Timo D. Müller, Matthias H. Tschöp, Stephen O'Rahilly

Medicine and Health

Research output: Contribution to journal › Short survey › peer-review

12 Scopus citations

Abstract

Pro-opiomelanocortin deficiency is a rare cause of severe intractable obesity. Two patients have experienced dramatic weight loss in response to setmelanotide, a melanocortin-4 receptor activator. The drug has potential in broader populations, but caution is warranted as it may act at other melanocortin receptors.

Original language	English
Pages (from-to)	194-195
Number of pages	2
Journal	Cell Metabolism
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2016.07.006
State	Published - 9 Aug 2016

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10.1016/j.cmet.2016.07.006

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title = "Metabolic Precision Medicines: Curing POMC Deficiency",

abstract = "Pro-opiomelanocortin deficiency is a rare cause of severe intractable obesity. Two patients have experienced dramatic weight loss in response to setmelanotide, a melanocortin-4 receptor activator. The drug has potential in broader populations, but caution is warranted as it may act at other melanocortin receptors.",

author = "M{\"u}ller, {Timo D.} and Tsch{\"o}p, {Matthias H.} and Stephen O'Rahilly",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

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day = "9",

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TY - JOUR

T1 - Metabolic Precision Medicines

T2 - Curing POMC Deficiency

AU - Müller, Timo D.

AU - Tschöp, Matthias H.

AU - O'Rahilly, Stephen

PY - 2016/8/9

Y1 - 2016/8/9

N2 - Pro-opiomelanocortin deficiency is a rare cause of severe intractable obesity. Two patients have experienced dramatic weight loss in response to setmelanotide, a melanocortin-4 receptor activator. The drug has potential in broader populations, but caution is warranted as it may act at other melanocortin receptors.

AB - Pro-opiomelanocortin deficiency is a rare cause of severe intractable obesity. Two patients have experienced dramatic weight loss in response to setmelanotide, a melanocortin-4 receptor activator. The drug has potential in broader populations, but caution is warranted as it may act at other melanocortin receptors.

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U2 - 10.1016/j.cmet.2016.07.006

DO - 10.1016/j.cmet.2016.07.006

M3 - Short survey

C2 - 27452145

AN - SCOPUS:84991107659

SN - 1550-4131

VL - 24

SP - 194

EP - 195

JO - Cell Metabolism

JF - Cell Metabolism

IS - 2

ER -

Metabolic Precision Medicines: Curing POMC Deficiency

Abstract

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