Metabolic Precision Medicines: Curing POMC Deficiency

Timo D. Müller, Matthias H. Tschöp, Stephen O'Rahilly

Research output: Contribution to journalShort surveypeer-review

10 Scopus citations


Pro-opiomelanocortin deficiency is a rare cause of severe intractable obesity. Two patients have experienced dramatic weight loss in response to setmelanotide, a melanocortin-4 receptor activator. The drug has potential in broader populations, but caution is warranted as it may act at other melanocortin receptors.

Original languageEnglish
Pages (from-to)194-195
Number of pages2
JournalCell Metabolism
Issue number2
StatePublished - 9 Aug 2016


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