Membrane-bound heat shock protein 70 in acute myeloid leukemia: A tumor-specific recognition structure for the cytolytic activity of autologous natural killer cells

Mathias Gehrmann; Helga Schmetzer; Günther Eissner; Torsten Haferlach; Wolfgang Hiddemann; Gabriele Multhoff

Membrane-bound heat shock protein 70 in acute myeloid leukemia: A tumor-specific recognition structure for the cytolytic activity of autologous natural killer cells

Mathias Gehrmann, Helga Schmetzer, Günther Eissner, Torsten Haferlach, Wolfgang Hiddemann, Gabriele Multhoff

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Patients with de novo acute myeloid leukemia with unfavorable and intermediate cytogenetics are frequently heat shock protein 70 (Hsp70)-membrane-positive. In contrast, no Hsp70 was detected on bone marrow of healthy donors or on CD34-enriched cells. The leukemia-selective Hsp70-membrane expression provides a recognition structure for Hsp70-peptide stimulated, patient-derived natural killer cells.

Original language	English
Pages (from-to)	474-476
Number of pages	3
Journal	Haematologica
Volume	88
Issue number	4
State	Published - 1 Apr 2003
Externally published	Yes

Keywords

AML
Autologous NK cells
Cytolytic response
Hsp70-peptide
TKD

Cite this

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title = "Membrane-bound heat shock protein 70 in acute myeloid leukemia: A tumor-specific recognition structure for the cytolytic activity of autologous natural killer cells",

abstract = "Patients with de novo acute myeloid leukemia with unfavorable and intermediate cytogenetics are frequently heat shock protein 70 (Hsp70)-membrane-positive. In contrast, no Hsp70 was detected on bone marrow of healthy donors or on CD34-enriched cells. The leukemia-selective Hsp70-membrane expression provides a recognition structure for Hsp70-peptide stimulated, patient-derived natural killer cells.",

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T2 - A tumor-specific recognition structure for the cytolytic activity of autologous natural killer cells

AU - Gehrmann, Mathias

AU - Schmetzer, Helga

AU - Eissner, Günther

AU - Haferlach, Torsten

AU - Hiddemann, Wolfgang

AU - Multhoff, Gabriele

PY - 2003/4/1

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N2 - Patients with de novo acute myeloid leukemia with unfavorable and intermediate cytogenetics are frequently heat shock protein 70 (Hsp70)-membrane-positive. In contrast, no Hsp70 was detected on bone marrow of healthy donors or on CD34-enriched cells. The leukemia-selective Hsp70-membrane expression provides a recognition structure for Hsp70-peptide stimulated, patient-derived natural killer cells.

AB - Patients with de novo acute myeloid leukemia with unfavorable and intermediate cytogenetics are frequently heat shock protein 70 (Hsp70)-membrane-positive. In contrast, no Hsp70 was detected on bone marrow of healthy donors or on CD34-enriched cells. The leukemia-selective Hsp70-membrane expression provides a recognition structure for Hsp70-peptide stimulated, patient-derived natural killer cells.

KW - AML

KW - Autologous NK cells

KW - Cytolytic response

KW - Hsp70-peptide

KW - TKD

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M3 - Article

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VL - 88

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JO - Haematologica

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IS - 4

ER -

Membrane-bound heat shock protein 70 in acute myeloid leukemia: A tumor-specific recognition structure for the cytolytic activity of autologous natural killer cells

Abstract

Keywords

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