Melanoma-associated paraneoplastic retinopathy: Case report and review of the literature

K. Boeck; S. Hofmann; M. Klopfer; U. Ian; T. Schmidt; R. Engst; C. E. Thirkill; J. Ring

doi:10.1111/j.1365-2133.1997.tb03759.x

Melanoma-associated paraneoplastic retinopathy: Case report and review of the literature

K. Boeck
, S. Hofmann
, M. Klopfer
, U. Ian
, T. Schmidt
, R. Engst
, C. E. Thirkill
, J. Ring

Technical University of Munich
University of California, Davis

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

A 51-year-old white male suffering from metastatic malignant melanoma of the skin presented with lymph node metastases and paraneoplastic retinopathy 4 years after resection of the primary tumour. There were no cerebral metastases. Ocular symptoms consisting of night blindness and sensations of 'shimmering lights' persisted after total resection of the inguinal lymph node metastases and administration of dacarbazine and prednisone. Perimetry of both eyes was abnormal with concentric restriction. Electroretinography showed significantly reduced amplitudes in both eyes. Only 11 patients with melanoma-associated retinopathy (MAR) have been described. High titres of autoantibodies against whole retina extract were detected by enzyme-linked immunosorbent assay (ELISA) reactions. Indirect immunohistochemistry showed strong autoantibody activity against retinal bipolar cells.

Original language	English
Pages (from-to)	457-460
Number of pages	4
Journal	British Journal of Dermatology
Volume	137
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2133.1997.tb03759.x
State	Published - 1997

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10.1111/j.1365-2133.1997.tb03759.x

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title = "Melanoma-associated paraneoplastic retinopathy: Case report and review of the literature",

abstract = "A 51-year-old white male suffering from metastatic malignant melanoma of the skin presented with lymph node metastases and paraneoplastic retinopathy 4 years after resection of the primary tumour. There were no cerebral metastases. Ocular symptoms consisting of night blindness and sensations of 'shimmering lights' persisted after total resection of the inguinal lymph node metastases and administration of dacarbazine and prednisone. Perimetry of both eyes was abnormal with concentric restriction. Electroretinography showed significantly reduced amplitudes in both eyes. Only 11 patients with melanoma-associated retinopathy (MAR) have been described. High titres of autoantibodies against whole retina extract were detected by enzyme-linked immunosorbent assay (ELISA) reactions. Indirect immunohistochemistry showed strong autoantibody activity against retinal bipolar cells.",

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T1 - Melanoma-associated paraneoplastic retinopathy

T2 - Case report and review of the literature

AU - Boeck, K.

AU - Hofmann, S.

AU - Klopfer, M.

AU - Ian, U.

AU - Schmidt, T.

AU - Engst, R.

AU - Thirkill, C. E.

AU - Ring, J.

PY - 1997

Y1 - 1997

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AB - A 51-year-old white male suffering from metastatic malignant melanoma of the skin presented with lymph node metastases and paraneoplastic retinopathy 4 years after resection of the primary tumour. There were no cerebral metastases. Ocular symptoms consisting of night blindness and sensations of 'shimmering lights' persisted after total resection of the inguinal lymph node metastases and administration of dacarbazine and prednisone. Perimetry of both eyes was abnormal with concentric restriction. Electroretinography showed significantly reduced amplitudes in both eyes. Only 11 patients with melanoma-associated retinopathy (MAR) have been described. High titres of autoantibodies against whole retina extract were detected by enzyme-linked immunosorbent assay (ELISA) reactions. Indirect immunohistochemistry showed strong autoantibody activity against retinal bipolar cells.

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M3 - Article

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JO - British Journal of Dermatology

JF - British Journal of Dermatology

IS - 3

ER -

Melanoma-associated paraneoplastic retinopathy: Case report and review of the literature

Abstract

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