Abstract
Since ancient times gold and its complexes have been used as therapeutics against different diseases. In modern medicine gold drugs have been applied for the treatment of rheumatoid arthritis, however, recently other medical applications have come into the focus of inorganic medicinal chemistry. This chapter provides a non-comprehensive overview of key developments in the field of gold anticancer drugs. Exciting findings on gold(I) and gold(III) complexes as antitumor agents are summarized together with a discussion of relevant aspects of their modes of action.
| Original language | English |
|---|---|
| Title of host publication | Metallo-Drugs |
| Subtitle of host publication | Development and Action of Anticancer Agents |
| Publisher | Walter de Gruyter GmbH |
| Pages | 199-217 |
| Number of pages | 19 |
| ISBN (Electronic) | 9783110470734 |
| ISBN (Print) | 9783110469844 |
| DOIs | |
| State | Published - 5 Feb 2018 |
| Externally published | Yes |
Keywords
- Aquaporins
- Carbenes
- Dithiocarbamates
- Gold
- Metallodrugs
- Phosphanes
- Porphyrins
- Thioredoxin reductase