Medicinal chemistry of gold anticancer metallodrugs

Angela Casini, Raymond Wai Yin Sun, Ingo Ott

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

50 Scopus citations


Since ancient times gold and its complexes have been used as therapeutics against different diseases. In modern medicine gold drugs have been applied for the treatment of rheumatoid arthritis, however, recently other medical applications have come into the focus of inorganic medicinal chemistry. This chapter provides a non-comprehensive overview of key developments in the field of gold anticancer drugs. Exciting findings on gold(I) and gold(III) complexes as antitumor agents are summarized together with a discussion of relevant aspects of their modes of action.

Original languageEnglish
Title of host publicationMetallo-Drugs
Subtitle of host publicationDevelopment and Action of Anticancer Agents
PublisherWalter de Gruyter GmbH
Number of pages19
ISBN (Electronic)9783110470734
ISBN (Print)9783110469844
StatePublished - 5 Feb 2018
Externally publishedYes


  • Aquaporins
  • Carbenes
  • Dithiocarbamates
  • Gold
  • Metallodrugs
  • Phosphanes
  • Porphyrins
  • Thioredoxin reductase


Dive into the research topics of 'Medicinal chemistry of gold anticancer metallodrugs'. Together they form a unique fingerprint.

Cite this