TY - JOUR
T1 - Medical approaches and future options in chronic activate ulcerative colitis
AU - Siveke, J. T.
AU - Folwaczny, Christian
PY - 2004/7
Y1 - 2004/7
N2 - Background: Immunosuppressive therapy employing purine analogues is the therapeutic mainstay in patients with chronic active ulcerative colitis. However, despite therapeutic optimization according to thiopurine-methyltransferase activity or red blood cell 6-thioguanine levels, a substantial proportion of patients does not tolerate azathioprine or 6-mercaptopurine or relapses during this treatment. In the latter multiple therapeutic regimens comprising 6-thioguanine, cyclosporin or tacrolimus, methotrexate, cyclophosphamide, infliximab, interferons, heparin, leukocyte apheresis, and various other regimens might be considered aiming at long-term remission. Many of these treatment forms have only been evaluated in small mostly uncontrolled trials. Objective: In this review existing treatment modalities and future options for patients with chronic active ulcerative colitis will be discussed focusing on immunomodulating approaches.
AB - Background: Immunosuppressive therapy employing purine analogues is the therapeutic mainstay in patients with chronic active ulcerative colitis. However, despite therapeutic optimization according to thiopurine-methyltransferase activity or red blood cell 6-thioguanine levels, a substantial proportion of patients does not tolerate azathioprine or 6-mercaptopurine or relapses during this treatment. In the latter multiple therapeutic regimens comprising 6-thioguanine, cyclosporin or tacrolimus, methotrexate, cyclophosphamide, infliximab, interferons, heparin, leukocyte apheresis, and various other regimens might be considered aiming at long-term remission. Many of these treatment forms have only been evaluated in small mostly uncontrolled trials. Objective: In this review existing treatment modalities and future options for patients with chronic active ulcerative colitis will be discussed focusing on immunomodulating approaches.
KW - Antisense
KW - Chronic active ulcerative colitis
KW - Cytokines
KW - Heparin
KW - Immunosuppression
UR - http://www.scopus.com/inward/record.url?scp=3042767603&partnerID=8YFLogxK
U2 - 10.1007/s00384-003-0569-x
DO - 10.1007/s00384-003-0569-x
M3 - Review article
C2 - 14727131
AN - SCOPUS:3042767603
SN - 0179-1958
VL - 19
SP - 297
EP - 307
JO - International Journal of Colorectal Disease
JF - International Journal of Colorectal Disease
IS - 4
ER -