Mediating specific cell adhesion to low-adhesive diblock copolymers by instant modification with RGD-peptides

M. Hacker, E. Lieb, J. Tessmar, J. Fiedler, C. Dahmen, U. Hersel, H. Kessler, M. B. Schulz, A. Göpferich

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The modification of low-adhesive diblock copolymers with RGD-peptides to mediate specific cell adhesion was described. Human osteoblast known to express the corresponding integrins were used to determine cell-polymer interactions. The low-adhesive surfaces were modified by covalently attaching cyclic RGD-peptides in an instant procedure. It was observed that all RGD-modified polymer films showed increased cell adhesion. Cells were widely spread on the RGD-peptide modified films, indicating strong cell-surface interactions.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Pages1101
Number of pages1
StatePublished - 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: 17 May 200421 May 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Conference

ConferenceTransactions - 7th World Biomaterials Congress
Country/TerritoryAustralia
CitySydney
Period17/05/0421/05/04

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