Mechanisms underlying the cytotoxic activity of syn/anti-isomers of dinuclear Au(I) NHC complexes

Keyphrases

• Dinuclear 100%
• Au(I) Complex 100%
• Mesityl 100%
• Pd-NHC Complex 100%
• Hexafluorophosphate 100%
• N-substituent 100%
• Antiproliferative Activity 100%
• Cytotoxic Activity 100%
• Cancer Cell Lines 100%
• Selectivity Index 100%
• Dinuclear Complexes 50%
• Elemental Analysis 50%
• NMR Spectroscopy 50%
• Chloride 50%
• High Selectivity 50%
• Steric Hindrance 50%
• Hydrogen Bonding Interaction 50%
• Dissociation 50%
• Nucleophilic 50%
• Isopropyl 50%
• Density Functional Calculations 50%
• Nucleophilic Attack 50%
• Thiols 50%
• Cysteine 50%
• Reversed-phase HPLC 50%
• Oxidative Stress 50%
• Inductively Coupled Plasma Mass Spectrometry 50%
• ESI Mass Spectrometry 50%
• MCF-7 Cells 50%
• Thioredoxin Reductase 50%
• Auranofin 50%
• Water Solubility 50%
• Inhibition Properties 50%
• Mitochondria-associated Membranes 50%
• Distribution Studies 50%
• Mechanistic Studies 50%
• Cellular Distribution 50%
• X-ray Diffraction (XRD) Analysis 50%
• Low Reactivity 50%
• Counterion Exchange 50%
• Nuclear Microscopy 50%
• TrxR Inhibitor 50%

Chemistry

• Antiproliferative 100%
• Elemental Analysis 50%
• Single Crystal X-Ray Diffraction 50%
• X-Ray Diffraction 50%
• Steric Hindrance 50%
• Hydrogen Bonding 50%
• Mechanistic Study 50%
• Electrospray Ionization Mass Spectrometry 50%
• L-Cysteine 50%
• Inductively Coupled Plasma Method 50%
• Reversed Phase HPLC 50%
• NMR Spectroscopy 50%
• Density Functional Theory 50%
• Thiol 50%
• Cysteine 50%
• Ion Exchange 50%
• Subcellular Localization 50%
• Thioredoxin 50%
• Auranofin 50%
• Oxidative Stress 50%