TY - JOUR
T1 - Maternal smoking during pregnancy and early childhood and development of asthma and rhinoconjunctivitis - a MeDALL project
AU - Thacher, Jesse D.
AU - Gehring, Ulrike
AU - Gruzieva, Olena
AU - Standi, Marie
AU - Pershagen, Göran
AU - Bauer, Carl Peter
AU - Berdel, Dietrich
AU - Keller, Theresa
AU - Koletzko, Sibylle
AU - Koppelman, Gerard H.
AU - Kull, Inger
AU - Lau, Susanne
AU - Lehmann, Irina
AU - Maier, Dieter
AU - Schikowski, Tamara
AU - Wahn, Ulrich
AU - Wijga, Alet H.
AU - Heinrich, Joachim
AU - Bousquet, Jean
AU - Anto, Josep M.
AU - Berg, Andrea von
AU - Melén, Erik
AU - Smit, Henriette A.
AU - Keil, Thomas
AU - Bergström, Anna
N1 - Publisher Copyright:
© 2018, Public Health Services, US Dept of Health and Human Services. All rights reserved.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - BACKGROUND: The role of tobacco smoke exposure in the development and persistence of asthma and rhinoconjunctivitis through childhood into adolescence is unclear. OBJECTIVES: We assessed the associations of parental smoking from fetal life through adolescence with asthma and rhinoconjunctivitis during childhood and adolescence. METHODS: We analyzed data for 10,860 participants of five European birth cohort studies from the Mechanisms of the Development of Allergy (MeDALL) consortium. Parental smoking habits and health outcomes (early transient, persistent, and adolescent-onset asthma and rhinoconjunctivitis) were based on questionnaires covering the period from pregnancy to 14-16 y of age. Data were combined and analyzed using a one-stage and two-stage individual participant data meta-analysis. RESULTS: Overall, any maternal smoking during pregnancy tended to be associated with an increased odds of prevalent asthma [adjusted oddsratio (aOR) = 1.19 (95% CI: 0.98, 1.43)], but not prevalent rhinoconjunctivitis [aOR= 1.05 (95% CI: 0.90, 1.22)], during childhood and adolescence. In analyses with phenotypes related to age of onset and persistence of disease, any maternal smoking during pregnancy was associated with early transient asthma [aOR= 1.79 (95% CI: 1.14, 2.83)]. Maternal smoking of <10cigarettes/day during pregnancy was associated with persistent asthma [aOR= 1.66 (95% CI: 1.29, 2.15)] and persistent rhinoconjunctivitis [aOR= 1.55 (95% CI, 1.09, 2.20)]. Tobacco smoke exposure during fetal life, infancy, childhood, and adolescence was not associated with adolescent-onset asthma or rhinoconjunctivitis. CONCLUSIONS: Findings from this combined analysis of five European birth cohorts strengthen evidence linking early exposure to tobacco smoke with asthma during childhood and adolescence. Children with high early-life exposure were more likely than unexposed children to have early transient and persistent asthma and persistent rhinoconjunctivitis.
AB - BACKGROUND: The role of tobacco smoke exposure in the development and persistence of asthma and rhinoconjunctivitis through childhood into adolescence is unclear. OBJECTIVES: We assessed the associations of parental smoking from fetal life through adolescence with asthma and rhinoconjunctivitis during childhood and adolescence. METHODS: We analyzed data for 10,860 participants of five European birth cohort studies from the Mechanisms of the Development of Allergy (MeDALL) consortium. Parental smoking habits and health outcomes (early transient, persistent, and adolescent-onset asthma and rhinoconjunctivitis) were based on questionnaires covering the period from pregnancy to 14-16 y of age. Data were combined and analyzed using a one-stage and two-stage individual participant data meta-analysis. RESULTS: Overall, any maternal smoking during pregnancy tended to be associated with an increased odds of prevalent asthma [adjusted oddsratio (aOR) = 1.19 (95% CI: 0.98, 1.43)], but not prevalent rhinoconjunctivitis [aOR= 1.05 (95% CI: 0.90, 1.22)], during childhood and adolescence. In analyses with phenotypes related to age of onset and persistence of disease, any maternal smoking during pregnancy was associated with early transient asthma [aOR= 1.79 (95% CI: 1.14, 2.83)]. Maternal smoking of <10cigarettes/day during pregnancy was associated with persistent asthma [aOR= 1.66 (95% CI: 1.29, 2.15)] and persistent rhinoconjunctivitis [aOR= 1.55 (95% CI, 1.09, 2.20)]. Tobacco smoke exposure during fetal life, infancy, childhood, and adolescence was not associated with adolescent-onset asthma or rhinoconjunctivitis. CONCLUSIONS: Findings from this combined analysis of five European birth cohorts strengthen evidence linking early exposure to tobacco smoke with asthma during childhood and adolescence. Children with high early-life exposure were more likely than unexposed children to have early transient and persistent asthma and persistent rhinoconjunctivitis.
UR - https://www.scopus.com/pages/publications/85045472295
U2 - 10.1289/EHP2738
DO - 10.1289/EHP2738
M3 - Article
C2 - 29664587
AN - SCOPUS:85045472295
SN - 0091-6765
VL - 126
SP - 047005-1-047005-13
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
IS - 4
ER -
