TY - JOUR
T1 - Maternal haemoglobin levels in pregnancy and child DNA methylation
T2 - a study in the pregnancy and childhood epigenetics consortium
AU - Ronkainen, Justiina
AU - Heiskala, Anni
AU - Vehmeijer, Florianne O.L.
AU - Lowry, Estelle
AU - Caramaschi, Doretta
AU - Estrada Gutierrez, Guadalupe
AU - Heiss, Jonathan A.
AU - Hummel, Nadine
AU - Keikkala, Elina
AU - Kvist, Tuomas
AU - Kupsco, Allison
AU - Melton, Phillip E.
AU - Pesce, Giancarlo
AU - Soomro, Munawar H.
AU - Vives-Usano, Marta
AU - Baiz, Nour
AU - Binder, Elisabeth
AU - Czamara, Darina
AU - Guxens, Mònica
AU - Mustaniemi, Sanna
AU - London, Stephanie J.
AU - Rauschert, Sebastian
AU - Vääräsmäki, Marja
AU - Vrijheid, Martine
AU - Ziegler, Anette G.
AU - Annesi-Maesano, Isabella
AU - Bustamante, Mariona
AU - Huang, Rae Chi
AU - Hummel, Sandra
AU - Just, Allan C.
AU - Kajantie, Eero
AU - Lahti, Jari
AU - Lawlor, Deborah
AU - Räikkönen, Katri
AU - Järvelin, Marjo Riitta
AU - Felix, Janine F.
AU - Sebert, Sylvain
N1 - Publisher Copyright:
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - Altered maternal haemoglobin levels during pregnancy are associated with pre-clinical and clinical conditions affecting the fetus. Evidence from animal models suggests that these associations may be partially explained by differential DNA methylation in the newborn with possible long-term consequences. To test this in humans, we meta-analyzed the epigenome-wide associations of maternal haemoglobin levels during pregnancy with offspring DNA methylation in 3,967 newborn cord blood and 1,534 children and 1,962 adolescent whole-blood samples derived from 10 cohorts. DNA methylation was measured using Illumina Infinium Methylation 450K or MethylationEPIC arrays covering 450,000 and 850,000 methylation sites, respectively. There was no statistical support for the association of maternal haemoglobin levels with offspring DNA methylation either at individual methylation sites or clustered in regions. For most participants, maternal haemoglobin levels were within the normal range in the current study, whereas adverse perinatal outcomes often arise at the extremes. Thus, this study does not rule out the possibility that associations with offspring DNA methylation might be seen in studies with more extreme maternal haemoglobin levels.
AB - Altered maternal haemoglobin levels during pregnancy are associated with pre-clinical and clinical conditions affecting the fetus. Evidence from animal models suggests that these associations may be partially explained by differential DNA methylation in the newborn with possible long-term consequences. To test this in humans, we meta-analyzed the epigenome-wide associations of maternal haemoglobin levels during pregnancy with offspring DNA methylation in 3,967 newborn cord blood and 1,534 children and 1,962 adolescent whole-blood samples derived from 10 cohorts. DNA methylation was measured using Illumina Infinium Methylation 450K or MethylationEPIC arrays covering 450,000 and 850,000 methylation sites, respectively. There was no statistical support for the association of maternal haemoglobin levels with offspring DNA methylation either at individual methylation sites or clustered in regions. For most participants, maternal haemoglobin levels were within the normal range in the current study, whereas adverse perinatal outcomes often arise at the extremes. Thus, this study does not rule out the possibility that associations with offspring DNA methylation might be seen in studies with more extreme maternal haemoglobin levels.
KW - DNA methylation
KW - Maternal haemoglobin
KW - developmental programming
KW - pregnancy
UR - http://www.scopus.com/inward/record.url?scp=85099373127&partnerID=8YFLogxK
U2 - 10.1080/15592294.2020.1864171
DO - 10.1080/15592294.2020.1864171
M3 - Article
C2 - 33331245
AN - SCOPUS:85099373127
SN - 1559-2294
VL - 17
SP - 19
EP - 31
JO - Epigenetics
JF - Epigenetics
IS - 1
ER -
