TY - JOUR
T1 - Mass density measurement of mineralized tissue with grating-based X-Ray phase tomography
AU - Gradl, Regine
AU - Zanette, Irene
AU - Ruiz-Yaniz, Maite
AU - Dierolf, Martin
AU - Rack, Alexander
AU - Zaslansky, Paul
AU - Pfeiffer, Franz
N1 - Publisher Copyright:
© 2016 Gradl et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2016/12
Y1 - 2016/12
N2 - Establishing the mineral content distribution in highly mineralized tissues, such as bones and teeth, is fundamental in understanding a variety of structural questions ranging from studies of the mechanical properties to improved pathological investigations. However, nondestructive, volumetric and quantitative density measurements of mineralized samples, some of which may extend several mm in size, remain challenging. Here, we demonstrate the potential of grating-based x-ray phase tomography to gain insight into the three-dimensional mass density distribution of tooth tissues in a non-destructive way and with a sensitivity of 85 mg/cm3 . Density gradients of 13 - 19% over 1 - 2 mm within typical samples are detected, and local variations in density of 0.4 g/cm3 on a length scale of 0.1 mm are revealed. This method proves to be an excellent quantitative tool for investigations of subtle differences in mineral content of mineralized tissues that can change following treatment or during ageing and healing.
AB - Establishing the mineral content distribution in highly mineralized tissues, such as bones and teeth, is fundamental in understanding a variety of structural questions ranging from studies of the mechanical properties to improved pathological investigations. However, nondestructive, volumetric and quantitative density measurements of mineralized samples, some of which may extend several mm in size, remain challenging. Here, we demonstrate the potential of grating-based x-ray phase tomography to gain insight into the three-dimensional mass density distribution of tooth tissues in a non-destructive way and with a sensitivity of 85 mg/cm3 . Density gradients of 13 - 19% over 1 - 2 mm within typical samples are detected, and local variations in density of 0.4 g/cm3 on a length scale of 0.1 mm are revealed. This method proves to be an excellent quantitative tool for investigations of subtle differences in mineral content of mineralized tissues that can change following treatment or during ageing and healing.
UR - http://www.scopus.com/inward/record.url?scp=85007362142&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0167797
DO - 10.1371/journal.pone.0167797
M3 - Article
C2 - 28002416
AN - SCOPUS:85007362142
SN - 1932-6203
VL - 11
JO - PLoS ONE
JF - PLoS ONE
IS - 12
M1 - e0167797
ER -