Marrow grafts in LD SD typed dogs treated with cyclophosphamide

H. J. Kolb, I. Rieder, H. Grosse Wilde

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

One MHC haplotype different siblings are better marrow donors than two haplotype different unrelated individuals. Furthermore, additional partial matching of the different haplotype is valuable for achieving engraftment and mitigating GVHD. For acceptance of the graft and prevention of GVHD, compatibility of LD and SD determinants appears to be more important than identity. Early graft failures that may be due to allogeneic resistance can be overcome by adding leukocyte concentrates to the CY conditioning regimen. Isolated LD differences apparently do not interfere with engraftment but do provoke severe GVHD.

Original languageEnglish
Pages (from-to)555-559
Number of pages5
JournalTransplantation Proceedings
Volume8
Issue number4
StatePublished - 1976
Externally publishedYes

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