Mapping of bovine markers CYP21, PRL, and BOLA DRBP1 by genetic linkage analysis in reference pedigrees

P. Creighton; A. Eggen; R. Fries; S. A. Jordan; J. Hetzel; E. P. Cunningham; P. Humphries

doi:10.1016/S0888-7543(05)80260-5

Mapping of bovine markers CYP21, PRL, and BOLA DRBP1 by genetic linkage analysis in reference pedigrees

P. Creighton, A. Eggen, R. Fries, S. A. Jordan, J. Hetzel, E. P. Cunningham, P. Humphries

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We have analyzed DNA from 13 bovine reference pedigrees using primers specific for microsatellite markers derived from the 21-steroid hydroxylase (CYP21) and prolactin (PRL) genes and the leukocyte antigen (BOLA DRBP1) pseudogene. Linkage was demonstrated between PRL and BOLA DRBP1 (θ{symbol} = 0.05; Z = 19.6), cyp21 and PRL (θ{symbol} = 0.13; Z = 6.8), and BOLA DRBP1 and CYP21 (θ{symbol} = 0.17; Z = 10.4). These results suggest an order BOLA DRBP1-PRL-CYP21, although in a multilocus analysis the alternative order PRL-BOLA DRBP1-CYP21 was also possible. The data confirm and extend the previously established syntenic relationship between these markers on bovine chromosome 23 and provide points of anchorage for further linkage studies in the reference pedigrees described.

Original language	English
Pages (from-to)	526-528
Number of pages	3
Journal	Genomics
Volume	14
Issue number	2
DOIs	https://doi.org/10.1016/S0888-7543(05)80260-5
State	Published - Oct 1992
Externally published	Yes

Access to Document

10.1016/S0888-7543(05)80260-5

Cite this

@article{6b9895c0b6344d19844f59c57c59ef98,

title = "Mapping of bovine markers CYP21, PRL, and BOLA DRBP1 by genetic linkage analysis in reference pedigrees",

abstract = "We have analyzed DNA from 13 bovine reference pedigrees using primers specific for microsatellite markers derived from the 21-steroid hydroxylase (CYP21) and prolactin (PRL) genes and the leukocyte antigen (BOLA DRBP1) pseudogene. Linkage was demonstrated between PRL and BOLA DRBP1 (θ{symbol} = 0.05; Z = 19.6), cyp21 and PRL (θ{symbol} = 0.13; Z = 6.8), and BOLA DRBP1 and CYP21 (θ{symbol} = 0.17; Z = 10.4). These results suggest an order BOLA DRBP1-PRL-CYP21, although in a multilocus analysis the alternative order PRL-BOLA DRBP1-CYP21 was also possible. The data confirm and extend the previously established syntenic relationship between these markers on bovine chromosome 23 and provide points of anchorage for further linkage studies in the reference pedigrees described.",

author = "P. Creighton and A. Eggen and R. Fries and Jordan, {S. A.} and J. Hetzel and Cunningham, {E. P.} and P. Humphries",

note = "Funding Information: The authors gratefully acknowledge the support of the Commission of the European Communities ECLAIR program and the Meat Research Corporation of Australia. They also thank Dr. J. Farrar for helpful advice.",

year = "1992",

month = oct,

doi = "10.1016/S0888-7543(05)80260-5",

language = "English",

volume = "14",

pages = "526--528",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Mapping of bovine markers CYP21, PRL, and BOLA DRBP1 by genetic linkage analysis in reference pedigrees

AU - Creighton, P.

AU - Eggen, A.

AU - Fries, R.

AU - Jordan, S. A.

AU - Hetzel, J.

AU - Cunningham, E. P.

AU - Humphries, P.

N1 - Funding Information: The authors gratefully acknowledge the support of the Commission of the European Communities ECLAIR program and the Meat Research Corporation of Australia. They also thank Dr. J. Farrar for helpful advice.

PY - 1992/10

Y1 - 1992/10

N2 - We have analyzed DNA from 13 bovine reference pedigrees using primers specific for microsatellite markers derived from the 21-steroid hydroxylase (CYP21) and prolactin (PRL) genes and the leukocyte antigen (BOLA DRBP1) pseudogene. Linkage was demonstrated between PRL and BOLA DRBP1 (θ{symbol} = 0.05; Z = 19.6), cyp21 and PRL (θ{symbol} = 0.13; Z = 6.8), and BOLA DRBP1 and CYP21 (θ{symbol} = 0.17; Z = 10.4). These results suggest an order BOLA DRBP1-PRL-CYP21, although in a multilocus analysis the alternative order PRL-BOLA DRBP1-CYP21 was also possible. The data confirm and extend the previously established syntenic relationship between these markers on bovine chromosome 23 and provide points of anchorage for further linkage studies in the reference pedigrees described.

AB - We have analyzed DNA from 13 bovine reference pedigrees using primers specific for microsatellite markers derived from the 21-steroid hydroxylase (CYP21) and prolactin (PRL) genes and the leukocyte antigen (BOLA DRBP1) pseudogene. Linkage was demonstrated between PRL and BOLA DRBP1 (θ{symbol} = 0.05; Z = 19.6), cyp21 and PRL (θ{symbol} = 0.13; Z = 6.8), and BOLA DRBP1 and CYP21 (θ{symbol} = 0.17; Z = 10.4). These results suggest an order BOLA DRBP1-PRL-CYP21, although in a multilocus analysis the alternative order PRL-BOLA DRBP1-CYP21 was also possible. The data confirm and extend the previously established syntenic relationship between these markers on bovine chromosome 23 and provide points of anchorage for further linkage studies in the reference pedigrees described.

UR - http://www.scopus.com/inward/record.url?scp=0026441479&partnerID=8YFLogxK

U2 - 10.1016/S0888-7543(05)80260-5

DO - 10.1016/S0888-7543(05)80260-5

M3 - Article

C2 - 1427873

AN - SCOPUS:0026441479

SN - 0888-7543

VL - 14

SP - 526

EP - 528

JO - Genomics

JF - Genomics

IS - 2

ER -

Mapping of bovine markers CYP21, PRL, and BOLA DRBP1 by genetic linkage analysis in reference pedigrees

Abstract

Access to Document

Other files and links

Fingerprint

Cite this