Manual MRI morphometry in Parkinsonian syndromes

Leona Möller, Jan Kassubek, Martin Südmeyer, Rüdiger Hilker, Elke Hattingen, Karl Egger, Florian Amtage, Elmar H. Pinkhardt, Gesine Respondek, Maria Stamelou, Franz Möller, Alfons Schnitzler, Wolfgang H. Oertel, Susanne Knake, Hans Jürgen Huppertz, Günter U. Höglinger

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Background: Several morphometric magnetic resonance imaging parameters may serve for differential diagnosis of parkinsonism. The objective of this study was to identify which performs best in clinical routine. Methods: We acquired multicentric magnetization-prepared rapid gradient echo sequences in patients with Parkinson's disease (n=204), progressive supranuclear palsy (n=106), multiple system atrophy-cerebellar, (n = 21); multiple system atrophy-parkinsonian (n = 60), and healthy controls (n = 73), performed manual planimetric measurements, and calculated receiver operator characteristics with leave-one-out cross-validation to propose cutoff values. Results: The midsagittal midbrain area was reduced in PSP versus all other groups (P < 0.001). The midsagittal pons area was reduced in MSA-cerebellar, MSA-parkinsonian, and PSP versus PD patients and healthy controls (P < 0.001). The midbrain/pons area ratio was lower in PSP (P < 0.001) and higher in MSA-cerebellar and MSA-parkinsonian versus PD and PSP (P < 0.001). Conclusions: The midsagittal midbrain area most reliably identified PSP, the midsagittal pons area MSA-cerebellar. The midbrain/pons area ratio differentiated MSA-cerebellar and PSP better than the magnetic resonance-Parkinson index.

Original languageEnglish
Pages (from-to)778-782
Number of pages5
JournalMovement Disorders
Volume32
Issue number5
DOIs
StatePublished - May 2017

Keywords

  • Parkinson's disease
  • magnetic resonance imaging
  • morphometry
  • multiple system atrophy
  • progressive supranuclear palsy

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