Manifold learning for automatically predicting articular cartilage morphology in the knee with data from the osteoarthritis initiative (OAI)

C. Donoghue, A. Rao, A. M.J. Bull, D. Rueckert

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

5 Scopus citations


Osteoarthritis (OA) is a degenerative, debilitating disease with a large socio-economic impact. This study looks to manifold learning as an automatic approach to harness the plethora of data provided by the Osteoarthritis Initiative (OAI). We construct several Laplacian Eigenmap embeddings of articular cartilage appearance from MR images of the knee using multiple MR sequences. A region of interest (ROI) defined as the weight bearing medial femur is automatically located in all images through non-rigid registration. A pairwise intensity based similarity measure is computed between all images, resulting in a fully connected graph, where each vertex represents an image and the weight of edges is the similarity measure. Spectral analysis is then applied to these pairwise similarities, which acts to reduce the dimensionality non-linearly and embeds these images in a manifold representation. In the manifold space, images that are close to each other are considered to be more "similar" than those far away. In the experiment presented here we use manifold learning to automatically predict the morphological changes in the articular cartilage by using the co-ordinates of the images in the manifold as independent variables for multiple linear regression. In the study presented here five manifolds are generated from five sequences of 390 distinct knees. We find statistically significant correlations (up to R2 = 0.75), between our predictors and the results presented in the literature.

Original languageEnglish
Title of host publicationMedical Imaging 2011
Subtitle of host publicationImage Processing
StatePublished - 2011
Externally publishedYes
EventMedical Imaging 2011: Image Processing - Lake Buena Vista, FL, United States
Duration: 14 Feb 201116 Feb 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2011: Image Processing
Country/TerritoryUnited States
CityLake Buena Vista, FL


  • Articular Cartilage
  • Knee
  • Laplacian Eigenmap
  • Manifold Learning
  • Morphology
  • OAI
  • Osteoarthritis
  • Osteoarthritis Initiative


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